兔VX2肝癌MSCT评价及病理特征  

Multislice spiral CT evaluation and pathological characteristics of VX2 hepatic tumors in rabbits

作　　者：杨林[1] 周翔平[1] 官泳松[1] 李祖茂[2] 郭兴[1] 李肖[1] 孙家瑜[1] 

机构地区：[1]四川大学华西医院放射科,四川成都610041 [2]川北医学院病理学教研室,四川南充637000

出　　处：《中国医学影像技术》2007年第4期623-625,共3页Chinese Journal of Medical Imaging Technology

摘　　要：目的探讨兔VX2肝癌的CT表现及其病理特征。方法采用开腹瘤块包埋法建立兔VX2肝癌模型,分别于接种后2周和3周,应用Philips64层螺旋CT对实验兔进行CT平扫和增强双期扫描,CT检查完成后处死实验兔,进行病理学检查。结果16只兔均接种成功,在CT平扫,瘤灶表现为低密度,增强扫描,瘤灶在肝动脉期表现为不同程度的环形强化,门脉期呈低密度,与周围肝组织分界清楚;病理学检查见肿瘤呈结节状,突出于肝表面,部分有包膜,切面呈灰白色,与周围正常肝组织分界清楚;光镜下,癌细胞呈巢状分布,细胞较大,形态不规则,排列紊乱,血窦多,胞核大而深染,胞质量少。结论兔VX2肝癌病理表现呈结节状,与正常肝组织分界清楚,光镜下癌细胞呈巢状分布,异型性明显;MSCT可以准确地监测其生长情况。Objective To study the pathological characteristic of VX2 hepatic tumor in rabbit and the value of muhislice spiral CT （MSCT） in detecting this tumor model. Methods The plain and dual-phase enhanced CT were performed in 16 New Zealand white rabbits at 2 and 3 weeks after VX2 hepatic tumor implantation. After that, all the rabbits were executed and pathological examination was performed. Results Sixteen （100%） rabbits were successfully implanted with VX2 tumor in the liver. The tumors demonstrated themselves as hypodensity on plain CT scan, ring-enhanced on arterial phase images, hypodensity on portal phase images. In pathological examination, the tumors were exserted to the liver surface, the cross sections of the tumor were gray, the cells of the tumors are bigger and more hyperchromatic than the normal liver cells, arranged into nests with fibric tissue. Conclusion In pathological examination, the heteromorphism of VX2 tumor cell was conspicuous. The growth of VX2 hepatoma can be monitored by MSCT effectively.

关 键 词：VX2肿瘤 兔 模型 动物 体层摄影术 X线计算机 

分 类 号：R814.42[医药卫生—影像医学与核医学] Q95-3[医药卫生—放射医学]