肿瘤干细胞起源及其生物学特性  

The Origin and Biological Characteristics of Tumor Stem Cells

作　　者：陈晶[1] 蔡荣[1] 钱程[1] 

机构地区：[1]浙江理工大学生命科学学院新元医学与生物技术研究所,杭州310018

出　　处：《细胞生物学杂志》2007年第2期202-206,共5页Chinese Journal of Cell Biology

基　　金：国家重点基础研究发展规划(973计划)(No.2004CB518804);浙江省留学回国基金(No.116153A4I05038)资助项目~~

摘　　要：肿瘤干细胞与正常成体干细胞在自我更新与增殖分化能力、表型标记和强耐药性等诸多方面存在着相类似的生物学特征,所以肿瘤干细胞被推测为肿瘤发生的细胞起源。基于肿瘤干细胞与正常干细胞之间的相似性质和肿瘤发生的分子机制,科学家建立了一系列从肿瘤组织或肿瘤细胞系分离肿瘤干细胞的实验方法和研究肿瘤干细胞起源的动物实验模型。现就目前在肿瘤干细胞起源和生物学特性领域的研究作概括阐述。It is suspected that tumor stem cells give rise to tumorigenesis in that tumor stem cells share some biological characteristics with normal stem cells in self-renewal, proliferation ＆ differentiation, expression of same superficial markers and strong drug-resistance. According to the similarity between tumor stem cells and normal stem cells, scientists explored a series of scientific experiment methods and established a number of experiment models in order to separate tumor stem cells from tumor tissues or tumor cell lines and discover the origin of tumor stem cells. This review comprehensively explains the latest studies on the origin and biological characteristics of tumor stem cells.

关 键 词：肿瘤干细胞 成体干细胞 表型标记 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]