严重大面积烧伤连续血液净化对炎症介质的影响  

Effect of continuous blood purification on inflammatory factors in patients with severe large area burn

作　　者：姜会庆[1] 刘坤[1] 胡新宝[1] 解伟光[1] 汪军[1] 汪涌[1] 孙东燕[1] 陈一飞[1] 

机构地区：[1]南京军区南京总医院烧伤整形外科,210002

出　　处：《江苏医药》2007年第5期458-459,共2页Jiangsu Medical Journal

摘　　要：目的探讨连续血液净化(CBP)对严重大面积烧伤患者静脉血中炎症介质TNF-α、IL-6、IL-10水平的影响。方法12例严重大面积烧伤后接受CBP治疗的患者,分别于CBP治疗前和治疗后4、8、12h留取肝素抗凝静脉血5ml,检测外周血白细胞分类计数和血浆中TNF-α、IL-6和IL-10水平。结果CBP开始治疗4h内,患者TNF-α、IL-6和IL-10水平均有显著下降,但至12h又有所回升。随着治疗进行,白细胞总数及中性粒细胞所占百分比与CBP治疗前比较均显著降低(P<0·05)。结论CBP可明显减轻严重大面积烧伤患者白细胞应激状态,有效清除各种炎症介质,但需及时更换滤器,以维持疗效。Objective To investigate the dynamic changes of inflammatory factors in severe large area burn patients treated with continuous blood purification（CBP）. Methods Twelve severe patients with large burn area undergoing CBP were included in this study. Five ml venous samples were taken for the measurement of IL-6, TNF-α and IL-10 by radioimmunoassay before CBP, at 4, 8 and 12 h during CBP. White cell count was monitored as well. Results During 4 h CBP,the levels of IL-6,TNF-α and IL-10 were significantly decreased, which increased at 12 h. The percentage of neutrophil significantly decreased from 89.81 ± 2.86 % （ before CBP ） to 76.64 ± 8. 83 % （at 72 h ） （ P〈 0. 05）. Conclusion CBP could decrease neutrophil counts in peripheral venous blood and eliminate inflammation factors effectively in severe large area burn patients. To keep the efficient purification, the purification equiment should be changed in time.

关 键 词：血液净化 烧伤 炎症介质 

分 类 号：R644[医药卫生—外科学]