Facile Conversion of Alcohols to Olefins by Tosylation and Subsequent SiO_2-promoted β-elimination  

作　　者：RUAN Xiaohong SONG Gaopeng ZHANG Yichun LI Yingxia 

机构地区：[1]Key Laboratory of Marine Drugs of the Ministry of Education of China, School of Pharmacy, Ocean University of China, Qingdao 266003, P. R. China

出　　处：《Journal of Ocean University of China》2007年第2期196-198,共3页中国海洋大学学报（英文版）

摘　　要：A convenient and effective procedure was developed for the conversion of alcohol to olefin by tosylation and subsequent β-elimination promoted by silica gel in this study. Treatment of the alcohols with p-toluenesulfonyl chloride in pyridine at 0℃ af- fords tosylates which undergo β-elimination with silica gel in dichloromethane or chloroform at room temperature, yielding olefins with high productivity.A convenient and effective procedure was developed for the conversion of alcohol to olefin by tosylation and subsequent β-elimination promoted by silica gel in this study. Treatment of the alcohols with p-toluenesulfonyl chloride in pyridine at 0℃ affords tosylates which undergo β-elimination with silica gel in dichloromethane or chloroform at room temperature, yielding olefinswith high productivity.

关 键 词：alcohol TOSYLATION silica gel OLEFIN β-elimination 

分 类 号：O625.34[理学—有机化学]