超短波早期治疗对兔激素性股骨头缺血性坏死病理变化的影响  

The effects of early intervention with ultrashortwave diathermy on pathologic changes in hormone-induced ischemic necrosis of the femoral head

作　　者：孙强三[1] 徐青[1] 孙昭辉[1] 徐明[1] 

机构地区：[1]山东大学第二医院康复科,济南250033

出　　处：《中华物理医学与康复杂志》2007年第4期227-230,共4页Chinese Journal of Physical Medicine and Rehabilitation

基　　金：山东省科学技术发展计划重点项目(2004GG2202159)

摘　　要：目的研究超短波早期治疗对激素性股骨头缺血坏死病理变化的影响,并探讨其防治效果及作用机制。方法选择健康雄性新西兰兔30只,随机分成对照组、造模组、超短波组,采用马血清与激素联合造模制造兔激素性股骨头缺血性坏死模型,光镜观测12周末骨组织病理变化(成骨细胞破骨细胞计数、关节软骨厚度、软骨细胞空骨细胞陷窝率、软骨下血管计数、骨小梁宽度、脂肪细胞直径和脂肪细胞面积百分比的改变)。结果造模组成骨细胞计数比对照组显著减少,超短波组成骨细胞则较对照组显著增加(P<0.01);造模组和超短波组破骨细胞均较对照组显著增加,超短波组破骨细胞计数比造模组显著降低(P<0.05);造模组和超短波组软骨厚度均比对照组减少,超短波组较造模组显著增加(P<0.05);造模组和超短波组软骨细胞空骨陷窝率较对照组显著增加,造模组较超短波组增加显著(P<0.05);造模组软骨下血管计数较对照组显著减少,超短波组则比对照组显著增多(P<0.01);造模组和超短波组骨小梁宽度比对照组均减小,超短波组骨小梁宽度比造模组显著增加(P<0.01);造模组和超短波组脂肪细胞直径较对照组显著增大(P<0.01),超短波组脂肪细胞直径较对照组显著减少(P<0.05);造模组和超短波组脂肪细胞面积百分比(%)分别较对照组显著提高,超短波组较造模组显著降低(P<0.05)。结论超短波早期治疗兔激素性股骨头缺血性坏死有较好疗效。Objective： To investigate the pathogenesis of avascular necrosis of the femoral head（ANFH） and to observe the effects of uhrashortwave diathermy treatment of ANFH through animal experiments. Methods： A total of 30 New Zealand whiterabbits were randomly divided into three groups： a control group, a model group, and a diathermy group. All the groups were injected with horse serum and methylprednisolone to induce ANFH. The path- ological effects were observed. Results The amount of osteoblast in the model group was significantly less than in the control group, while in the diathermy group it was significantly increased compared with the control group. The a- mount of osteoclast in the model and diathermy groups was significantly higher than in the control group, and in the diathermy group it was significantly more than in the model group. The thickness of femoral head cartilage in the model and diathermy groups was reduced compared with the control group, while it was thicker in the model group than in the diathermy group. The empty cartilage cell lacunae ratios of the model and diathermy groups were significantly higher than for the control group, and the diathermy group showed significant degradation compared to the model group. The density of blood vessels under the cartilage in the model group was significantly less compared with the control group, while in the diathermy group it was significantly increased compared with the control group. The width of bone trabeculae in the model and diathermy groups was significantly less compared with the control group, while they were significantly wider in the diathermy group compared with the model group. The diameters of fat cells in the model and diathermy groups were increased compared with the control group, while they were significantly smaller in the dia- thermy group compared with the model group. The adipocyte area rates in the model and diathermy groups were significantly elevated compared with the control group, and rates in the model group were signifi

关 键 词：股骨头缺血性坏死 超短波 病理 兔 

分 类 号：R454[医药卫生—治疗学] R595.3[医药卫生—临床医学] R681.8