鸡球虫苗(LCV-2号)安全性和免疫效果研究  

Efficacy of the vaccine (LCV-2) against chicken coccidiosis

作　　者：闫鸿斌[1] 田广孚[1] 贾万忠[1] 林青[1] 李辉[1] 侯俊玲[1] 郑亚东[1] 程晓红[1] 宋玉霞[1] 才学鹏[1] 

机构地区：[1]中国农业科学院兰州兽医研究所家畜疫病病原生物学国家重点实验室/甘肃省动物寄生虫病重点实验室,甘肃兰州730046

出　　处：《中国预防兽医学报》2007年第5期368-371,共4页Chinese Journal of Preventive Veterinary Medicine

摘　　要：在实验条件下,研究了鸡球虫苗LCV-2号对笼养鸡的安全性和免疫保护效果.试验设空白对照组、攻虫对照组、免疫1组（1个免疫剂量）、免疫2组（2个免疫剂量）和免疫3组（0.5个免疫剂量）,共5个试验组,每组10只鸡.试验结果表明：①空白对照组、攻虫对照组和三个免疫组的相对增重率依次为100%、84.0%、96.9%、91.0%和91.0% ②攻虫后第8 d,每组剖检2只鸡,肠道病变记分5个组依次为0、4、1、3和4分.③免疫期间,免疫1、2和3组的每克粪便卵囊数（OPG）平均值依次为4.2×103个、9.2×103个和5.4×103个 攻虫期间,攻虫对照组5.117×105个、免疫1、2和3组依次为0.797×105个、0.522 × 105个和1.171×105个.④攻虫后各组死亡率依次为0、75%、25%、25%和50%.⑤抗球虫指数（ACI）,5个组依次为200.0、88.0、166.9、148.5和120.0.总的来看,免疫鸡群对大剂量卵囊攻击有较强的抵抗力,其中免疫1组结果良好,免疫2组和3组结果尚不理想,因此,LCV-2免疫1组的剂量（1头份卵囊/只）为优选剂量.This study examined the safety and efficacy of LCV-2 vaccine against coccidiosis in caged Lingnanhuang female broilers. The experiment was conducted in 5 trial groups （n=10）, including blank control, positive control, immunized group 1 （receiving 1 vaccine dose）, immunized group 2 （receiving 2 doses）, immunized group3 （receiving 0.5 dose）. The results showed that average ratio of weight gain of 5 groups were 100 % （blank control）, 84.0 % （positive control）, 96.9 % （immune group 1）, 91.0 % （immune group 2） and 91.0 % （immune group 3）, respectively. The intestinal lesion scores were 0, 4, 1, 3 and 4 for respective groups. The average OPG of 3 vaccinated groups were 4.2 x 103, 9.2 x 103 and 5.4 × 10^3. Following challenge infection, the OPG of the positive control and the 3 immunized groups were 5.117 × 10^5, 0.797 × 10^5, 0.522 × 10^5 and 1.171 × 10^5, respectively. The mortality rates of 5 groups were 0, 75 %, 25 %, 25 %, 50 %, and the ACI were 200.0, 88.0, 166.9, 148.5, and 120.0, respectively. In conclusion, the vaccinated chickens were better protected, with the immunized groupl performing the best.

关 键 词：鸡 球虫虫苗 免疫效果 

分 类 号：S852.723[农业科学—基础兽医学] S852.4[农业科学—兽医学]