离退休老干部血清不对称二甲基精氨酸和同型半胱氨酸的变化及其意义  

The changes and their significance of serum asymmetric dimethylarginine and homocysteine in elderly subjects

作　　者：陈景开[1] 王霄[1] 赵秋良[1] 吴刚勇[1] 陈满清[1] 张维维[1] 张丽[1] 

机构地区：[1]解放军第101医院心内科,江苏无锡214044

出　　处：《东南国防医药》2007年第2期81-83,共3页Military Medical Journal of Southeast China

摘　　要：目的探讨离退休老干部血清不对称二甲基精氨酸(ADMA)和同型半胱氨酸(Hcy)的变化及其意义。方法离退休老干部170例为观察组和健康者29例为对照组,测定其血压、血糖、血脂ADMA和Hcy等。结果观察组血清ADMA和Hcy分别为(0.91±0.54)μmol/L和(28.25±11.62)μmol/L,分别高于对照组的(0.56±0.10)μmol/L和(22.41±4.82)μmol/L(P<0.01)。观察组ADMA和Hcy大于正常值高限的发生率分别为32.35%和31.18%,显著高于血糖(20.59%)、总胆固醇(21.76%)、LDL-胆固醇(15.29%)和甘油三酯(21.76%)的异常发生率(P<0.05)。ADMA和Hcy异常亚组冠心病和高血压患病率显著高于ADMA和Hcy正常亚组的患病率(P<0.01)。经相关分析,观察组ADMA与Hcy之间不存在相关关系(P>0.05)。结论离退休老干部AD-MA和Hcy显著增高,其增高发生率高于血糖、血脂异常发生率。老干部冠心病和高血压患病率与ADMA和Hcy增高有关。ADMA与Hcy之间本身不存在相关关系。Objective To observe the changes and their significance of serum asymmetric dimethylarginine （ADMA） and homocysteine （Hcy） in elderly subjects, Methods The ADMA, Hcy, total cholesterol, triglycerides and glucose in serum were measured in 170 elderly subjects who were defined as observed group and 29 subjects of healthy as control group. Results The levels of ADMA and Hcy of the observed group were much higher than those of control group, they were （0. 91 ±0. 54）μmo]/L and （28.25±11.62）μmol/L in the observed group and were （0.56±0. 10）μmol/L and （22.41±4.82）μmol/L in control group （P〈 0. 01 ）. In the observed group, the percentage of ADMA and Hcy levels above the normal value were 32. 35% and 31. 18% respectively and much higher than those of glucose （20.59%）, total cholesterol （21. 76%）, LDL-cholesterol （15. 29%） and triglycerides （21. 76% ）（P〈0.01 ）. The observed group was divided into normal and abnormal subgroups according to the levels of ADMA and Hcy, it was found that prevalence rates of both coronary heart disease and hypertension were much higher in either ADMA or Hcy abnormal subgroup than in normal subgroups （P〈0. 017. There was no relationship between ADMA and Hcy in the observed group （P〈0.05）. Conclusion Compared to controls,the elderly have higher serum level of ADMA and Hcy, and either ADMA or Hcy abnormal subgroup has higher prevalence rates of both coronary heart disease and hypertension. There is no relationsk, ip between ADMA and Hcy.

关 键 词：老年人 不对称二甲基精氨酸 同型半胱氨酸 冠心病 高血压 

分 类 号：R541[医药卫生—心血管疾病]