急性心肌梗死患者血浆纤维蛋白原与C反应蛋白水平相关性研究  

The Relationship between Plasma Fibrinogen and C Reactive Protein in Patients with Acute Myocardial Infarction

作　　者：王骏[1] 王鸣和[1] 严铭玉[1] 周贇[1] 张雁[1] 孙育民[1] 唐琦[1] 胡雷光[1] 陈坚[1] 

机构地区：[1]上海市静安区中心医院心内科

出　　处：《世界临床药物》2007年第5期266-268,273,共4页World Clinical Drug

摘　　要：目的观察急性心肌梗死患者血浆纤维蛋白原(FIB)及C反应蛋白(CRP)水平,探讨两者间的关系以及对急性心肌梗死治疗的临床意义。方法测定经冠状动脉造影确诊为急性心肌梗死85例的血浆纤维蛋白原及C反应蛋白水平,分析FIB与CRP的相关性。结果偏相关分析显示,急性心肌梗死患者FIB与CRP明显相关,相关系数r=0.592,P<0.01。结论FIB不仅在凝血途径中起决定性作用,而且参与体内炎症反应,加剧冠脉病变进展,为一项简便易测的重要临床监测指标。Objective To investigate the relationship between the levels of plasma fibrinogen and C reactive protein, in patients with acute myocardial infarction. Methods The levels of plasma fibrinogen and C reactive protein were measured in 85 cases of acute myocardial infarction,using coronary angiography. The relationship between plasma fibrinogen and C reactive protein was analyzed. Result Partial correlation analysis showed that plasma fibrinogen was positively correlated with C reactive protein. (r =0.592, P<0.01). Conclusion Plasma fibrinogen participated in inflammatory reaction, aggravated evolution of diseased coronary artery as well as possessed decisive role in mechanism of blood coagulation.

关 键 词：急性心肌梗死 纤维蛋白原 C反应蛋白 

分 类 号：R542.22[医药卫生—心血管疾病]