人参茎叶总皂苷对衰老皮肤胶原纤维和弹力纤维的保护作用  

The protective effect of total Ginsenosides of stem and leaf on elastic and collagenous fiber on skin of aging mice

作　　者：李连昆 程俊霖[2] 赵妍妍[2] 范爱兰[2] 

机构地区：[1]武装警察部队四川总队成都医院内科 [2]四川大学基础与法医学院药理教研室

出　　处：《四川生理科学杂志》2007年第1期26-27,共2页Sichuan Journal of Physiological Sciences

摘　　要：目的:观察人参茎叶总皂苷口服对衰老皮肤弹力纤维和胶原纤维的作用。方法:小鼠颈背部皮下每日注射D-半乳糖(1000 mg.kg-1)造成衰老模型,同时灌胃50 mg.kg-1和100 mg.kg-1的人参茎叶总皂苷,42天后处死,10%甲醛固定。观察衰老皮肤胶原纤维和弹力纤维的改变。结果:50 mg.kg-1和100 mg.kg-1人参茎叶总皂苷使衰老小鼠皮肤中胶原纤维和弹力纤维的含量增加,100 mg.kg-1人参茎叶总皂苷作用更显著。结论:50 mg.kg-1和100 mg.kg-1人参茎叶总皂苷均对衰老皮肤的胶原纤维和弹力纤维有保护作用。Objective： To investigate the protective effect of Ginsenosides on elastic fiber and collagenous fiber in skin of the aging mice. Methods： The aging mice model was made by subcutaneous administration in cervix with a dose of D-galactose（1000 mg·kg^-1 ）daily for 42 days. At the same time, the aging mice took Ginsenosides（50 mg·kg^-1 or 100 mg·kg^-1） orally. After 42 days the skin tissue was fixed in 10% formaldehyde and the elastic fiber and collagenous fiber were checked. Results： Ginsenosides of 50 mg·kg^-1 and 100 mg·kg^-1 once daily for 42 d could significently increase the amount of elastic fiber and collagenous fiber in skin of the aging mice. And the effect of Ginsenosides of 100 mg/kg·d^-1 is more remarkable. Conelusion：Ginsenoside has remarkable protective effect on elastic fiber and collagenous fiber in skin of the aging mice.

关 键 词：人参茎叶总皂苷 胶原纤维 弹力纤维 

分 类 号：R285.5[医药卫生—中药学]