胰岛细胞抗体检测的临床意义  

The clinical significance of determining islet cell antibody

作　　者：彭永德[1] 胡远峰[1] 顾芷芳[1] 张洪德[1] 

机构地区：[1]上海市第一人民医院糖尿病研究室,安徽医科大学附属医院200080

出　　处：《上海医学》1997年第1期12-14,共3页Shanghai Medical Journal

摘　　要：本文对70例IDDM，84例NIDDM及14例自身免疫性疾病患者用ABC酶标法作了ICAb检测研究。结果显示：12例IDDM（17％）ICAb阳性，随病程延长阳性率与阳性滴度呈下降趋势，ICAb阳性者空腹C肽水平显著低于阴性者（P<0．05），行胰岛移植者ICAb阳性时移植物功能易于丧失，2例ICAb阳性NIDDM患者胰岛功能较差，需用胰岛素治疗，4例ICAb阳性自身免疫性性疾病患者行OGTT均正常，唯一例胰岛素释放呈低平曲线。提示ICAb可作为糖尿病易感个体鉴定、糖尿病分型，胰岛移植对象选择与移植物功能监测的重要免疫学标志。ICAb was detected by ABC enzyme-labelled method in 70 patients with lDDM, 84 with NIDDM and 14with autoimune diseases (AID). ICAb was found in l2 (17% ) IDDM patients, and its positive rate and titre were gradually declined with the duration of diabetes. The levels of fasting C-peptide in ICAb+IDDM patients were signifi-cantly lower than those in ICA-patients (P<0.05). The graft function in ICA+ recipients is easy to lose, 2 cases of NIDDM with positive lCA need insulin treatment. OGTT in 4 AID cases of ICA+ revealed normal, one case showed low insulin release. The results of the study indicated that ICA might be an important immunologic marker for identifying the individuals at risk of developing IDDM, classifying diabetes, selecting the suitable subjects for islet transplant and monitoring the fate of islet graft.

关 键 词：糖尿病 胰岛细胞 抗体 

分 类 号：R587.103[医药卫生—内分泌]