^(99)Tc^m-DTPA所测GFR评价肾功能估算公式的价值  

Validation of different algorithms in the estimation of GFR in Chinese

作　　者：马宏星[1] 王秀芹[2] 杨月莉[1] 陈雪民[1] 张炜[1] 王恒礼[1] 

机构地区：[1]同济大学附属同济医院核医学科,上海200065 [2]同济大学附属同济医院急诊科,上海200065

出　　处：《中华核医学杂志》2007年第1期28-30,共3页Chinese Journal of Nuclear Medicine

摘　　要：目的以肾小球滤过率(GFR)为标准,评价 Cockcroft-Gault、肾脏病膳食改良研究(MDRD)、简化 MDRD 及 Martin 公式在评估肾功能损伤中的价值。方法选择120例行 GFR 测定的非透析患者,以 MDRD、简化 MDRD 及 Martin 公式推算 GFR,以 Cockcroft-Gault 公式推算肌酐清除率,比较各推算值与 GFR 的差异及相关性。结果 Cockcroft-Gault 公式推算值与 GFR 值差异有显著性。MDRD、简化 MDRD 和 Martin 公式推算值仅在 GFR<80 ml·min^(-1)·(1.73 m^2)^(-1)时与 GFR 差异无显著性,但只有在 GFR<50 ml·min^(-1)·(1.73 m^2)^(-1)时与 GFR 有相关性。结论 Cockcroft-Gault 公式不适用于评价中国人肾功能受损的情况。MDRD、简化 MDRD 及 Martin 公式仅在 GFR<50 ml·min^(-1)·(1.73 m^2)^(-1)时可用于粗略评价中国人肾小球滤过功能受损情况。Objective The study was designed, to compare the Cockcroft-Ganlt formula, modification of diet in renal disease study （MDRD） formula, simplified MDRD formula and Martin formula in the estimation of glomeruiar filtration rate （GFR） to assess their validity in Chinese subjects. Methods One hundred and twenty patients without hemodialysis were included. The GFR estimated using Cockcroft-Gault formula, MDRD formula, simplified MDRD formula and Martin formula were compared with GFR assessed by Gate＇s method. Results GFRs estimated by Cockcroft-Gault formula were significandy different from that by the standard technique. GFRs estimated by MDRD formula, simplified MDRD formula and Martin formula were not significantly different from that of Gate＇ s method, provided that the GFR was lower than 80 ml·min^-1·（1.73 m^2）^ -1 but significant relationships were only existed among GFRs estimated by MDRD, simplified MDRD, Martin and by Gate＇ s method in case the GFR was lower than 50 ml·min^- 1 （ 1.73 m^2 ）^-1. Conclusions When the GFR is lower than 50 ml·min^- 1·（ 1.73 m^2 ）^-1, the MDRD, simplified MDRD and Martin formula may be used for their estimation among Chinese. But Cockcroft-Gault formula may not be suitable for the estimation.

关 键 词：肾小球滤过率 放射性核素显像 DTPA 方法 

分 类 号：R817.4[医药卫生—影像医学与核医学]