AECOPD住院期间cTnT预后价值初探  

A preliminary study on the prognostic value of cardiac tropinin T for in-hospital death in patients with acutely exacerbated chronic obstructive pulmonary disease

作　　者：陈峰[1] 张元霞[1] 王军[1] 徐海玲[1] 林殿杰[2] 

机构地区：[1]山东莱州市人民医院呼吸科,261400 [2]山东省立医院呼吸科

出　　处：《临床肺科杂志》2007年第6期593-595,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的评价cTnT在慢性阻塞性肺疾病急性加重期(AECOPD)住院期间的预后价值。方法采用前瞻性队列研究方法,测定82例AECOPD住院患者血清cTnT、Mb、CK-MBmass,收集患者临床资料,随访临床结局(死亡或存活)。采用单因素、Logistic回归分析进行预后分析。结果logistic多元回归分析结果显示,PaO2、cTnT增高、P(A-a)O2、年龄为AECOPD住院期间的主要预后因素(P<0.05)。结论cTnT增高是AECOPD住院期间的主要预后指标。Objective To assess the prognostic value of cTnT elevation during hospital stay for acute exacerbation of chronic obstructive pulmonary disease. Methods Eighty-two consecutive patients with confirmed acute exacerbation of chronic obstructive pulmonary disease were enrolled in this prospective study. Serum cTnT, myoglobin（ Mb）, creatine kinase-MB mass（CK-MBmass） were measured and a variety of clinical and laboratory variables were collected ,then followed up clinic outcome（ death and survival）. Univariate analysis and Logistic regression analysis was used to prognosis analysis. Results Age, PaO2 , P（A-a）O2 and cTnT elevation was identified as principal predictors of in-hospital death in a logistic regression model. Conclusions Elevated cTnT is a principal prognostic factor of inhospital death in patients admitted for acutely exacerbated chronic obstructive pulmonary disease.

关 键 词：慢性阻塞性肺疾病急性加重期 心肌肌钙蛋白T 预后价值 

分 类 号：R563.9[医药卫生—呼吸系统]