畏食症患儿血Ghrelin水平变化及与其胰岛素敏感性的关系  

Change of Level of Blood Ghrelin in Children with Anorexia and Its Relationship with Insulin Sensitivity

作　　者：陈志凤[1] 丘小汕[1] 赖峰[1] 肖满田[1] 

机构地区：[1]中山大学第一附属医院儿科,广州510080

出　　处：《实用儿科临床杂志》2007年第7期510-511,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的研究畏食症患儿血Ghrelin的水平变化及与胰岛素敏感性的关系,探讨Ghrelin在畏食发生、发展中的作用。方法分别测量40例畏食(畏食组)及20例健康儿童(对照组)的身高、体质量、体质量指数(BMI),测定血Ghrelin、胰岛素、血糖值,计算胰岛素敏感性指标(ISI),并对其结果进行对比分析。结果畏食组身高、体质量、BMI明显低于对照组;畏食组Ghrelin及ISI水平明显高于对照组,而血糖及胰岛素水平明显低于对照组,差异有显著性;二组Ghrelin水平均与ISI呈正相关,与血糖、胰岛素水平呈负相关。结论畏食症患儿食欲降低并非由Ghrelin分泌不足所致,畏食儿胰岛素敏感性增高可能是机体对高Ghrelin分泌水平反应。Objective To observe the change of the level of blood ghrelin in the children with anorexia and its relationship with insulin sensitivity. Methods Height, weight, body mass index（BMI） of 40 children in anorexia group ,20 healthy children in control group were meas- ured;the level of blood grelin,insulin and blood glucose were determined;insulin sensitivity index（ISI） was calculated, then the results in both groups were analyzed. Reults Levels of height, weight and BMI in anorexia group were significantly lower than those of control group. The ghrelin and ISI levels in anorexia group were significantly higher than those in Control group,but the insulin and glucose levels were significandy lower in anorexia group than those in control group,the differences were significant. Ghrelin level showed negative correlation with insulin and blood glucose concentration in both groups and positive correlation with ISI level. Conclusions The decrease of appetite in children with anorexia may not necessarily result from under - secretion of ghrelin. The increase of insulin sensitivity in children with anorexia may be a response to high level ofghrelin secretion.

关 键 词：畏食症 GHRELIN 儿童 

分 类 号：R725.7[医药卫生—儿科]