还原型谷胱甘肽降低糖尿病大鼠心肌NF-kB和诱导型一氧化氮合酶表达  

GSH treatment reduces the expressions of NF-kB and inducible nitrie oxide synthase in myocardium of diabetic rats

作　　者：卢斌[1] 王扬天[1] 狄红杰[1] 赵明[1] 

机构地区：[1]南京军区南京总医院内分泌科,210002

出　　处：《中华内分泌代谢杂志》2007年第2期172-173,共2页Chinese Journal of Endocrinology and Metabolism

摘　　要：以链脲佐菌素制备糖尿病大鼠模型,造模后以还原型谷胱甘肽(GSH)治疗12周,结果显示GSH治疗组较糖尿病组心肌组织病理学损害改善,NF-kB活性降低,诱导型一氧化氮合酶表达下降。Streptozotocin-induced diabetic rats were treated with GSH for 12 weeks. The results showed that GSH significantly improved the expressions of NF-κB and inducible nitrie oxide synthase and ameliorated the myocardial tissue injury.

关 键 词：糖尿病 心肌 NF—κB 一氧化氮合酶 谷胱甘肽 

分 类 号：R587.2[医药卫生—内分泌]