甲状腺功能减退症患儿血清生长激素、胰岛素样生长因子-Ⅰ、胰岛素样生长因子结合蛋白-3水平的变化  

Changes of Serum Growth Hormone,Insulin-Like Growth Factor-Ⅰ and Insulin-Like Growth Factor Binding Portein-3 Levels in Children with Hypothyroidism

作　　者：徐旭[1] 何勇[1] 沙红[1] 梅柏如[1] 

机构地区：[1]无锡市儿童医院内分泌科,江苏无锡214001

出　　处：《实用儿科临床杂志》2007年第8期603-604,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的通过监测甲状腺功能减退症患儿生长激素(GH)、胰岛素样生长因子-Ⅰ(IGF-Ⅰ)、胰岛素样生长因子结合蛋白-3(IGFBP-3)水平变化,探讨甲状腺功能减退症患儿GH-IGF轴与甲状腺素的变化规律。方法对56例甲状腺功能减退症(14例先天性甲状腺功能减退症和32例桥本病)患儿治疗前后血GH、IGF-Ⅰ、IGFBP-3水平和50例健康儿童血GH、IGF-Ⅰ、IGFBP-3水平进行监测。结果先天性甲状腺功能减退症新生儿9例患儿IGF-Ⅰ、IGFBP-3水平显著降低,经治疗后甲状腺功能逐渐恢复正常;5例先天性甲状腺功能减退症患儿和32例桥本病患儿无显著变化。结论先天性甲状腺功能减退症患儿存在GH-IGF轴功能紊乱,是导致身材矮小的重要原因,早期予甲状腺素治疗有利于维持患儿正常生长发育。Objective To detect the serum gyowth hormone（GH） ,insulin - like growth factor - Ⅰ（ⅠGF - Ⅰ ） ,insulin - like growth factor binging protein - 3 （ ⅠGFBP - 3 ） levels in children with hypothyroidism and explore the change regulation of GH - ⅠGF axis and thyroxine. Methods Fifty - six hypothyroidism children were divided into congonital hypothyroidism（CH） （ 14 cases） and Hashimoto＇s thyroiditis（32 cases） . Serum GH, ⅠGF - Ⅰ , ⅠGFBP - 3 levels of 56 hypothyroidism children before and after luothyruxine sodium L - T4 treatment and 50 normal children were detected with radioimmunoassay or enzyme - linked immunoserbent assay methods. Results Serum ⅠGF-Ⅰ, ⅠGFBP - 3 levels in 9 CH newborn group were lower, and they were normal after thyroxine substitute therapy. But those of 5 children with CH and 32 cases with Hashimoto＇s thyroiditis were not significantly changed. Conclusions The GH - ⅠGF axis is inordinate in the CH children ,which is an important reason of stature short. Early thyroxine substitute therapy is very helpful to maintain normal growth and development of children with CH.

关 键 词：甲状腺功能减退症 胰岛素样生长因子-Ⅰ 胰岛素样生长因子结合蛋白-3 

分 类 号：R725.8[医药卫生—儿科]