电针对慢性情绪应激焦虑模型大鼠行为学影响的研究  

Effect of Electroacupuncture on Behavioral Changes of Chronic Emotional Stress Anxiety Model Rats

作　　者：徐海洋[1] 周奇志[1] 王薇[1] 蔡定均[1] 李亮[1] 刘鸿燕[1] 孟都[1] 

机构地区：[1]成都中医药大学针灸推拿学院,四川成都610075

出　　处：《四川中医》2007年第5期97-99,共3页Journal of Sichuan of Traditional Chinese Medicine

基　　金：成都中医药大学校基金重点项目(编号:ZRZD200502);成都中医药大学针灸推拿重点学科科研开放基金(编号:10-7)

摘　　要：目的:观察电针对慢性情绪应激焦虑模型大鼠行为学的影响,探讨电针改善模型大鼠焦虑情绪的效应。方法:采用不可预知的情绪应激刺激方法,刺激大鼠21d,建立慢性情绪应激焦虑模型。电针“百会”、“三阴交”穴治疗21天,观察电针对大鼠体重的影响,并采用高架十字迷宫测试系统观测焦虑情绪的变化。结果:1.电针可使慢性情绪应激焦虑模型大鼠的体重有增加的趋势;2.电针可以提高慢性情绪应激焦虑模型大鼠进入开臂的次数(open-arms entries,OE)和在开臂停留时间(open-arms time,OT)分别占进入两臂总次数和滞留总时间的百分比(OE%和OT%值)(P<0.05,或P<0.01)。结论:电针可以降低焦虑模型大鼠的焦虑程度,具有明显抗焦虑的作用。Objective ： To observe the effect of electroacupuncture （ EA ） on behavioral changes of anxiety model rats of chronic emotional stress （CES）, so as to discuss the EA effects to decrease the anxiety level of model rats. Methods： Chronic emotional stress anxiety model was established by using unpredictable emotional stress method for 21 days. EA was applied to Baihui Point （GV20） and Sanyinjiao Point （SP6） for21 days. Then, researchers studied the effects of EA on rats＇ body weight, and observed the behavioral changes of model rats through Elevated Plus Maze Test System. Results ： 1. EA tended to increase the body weight of rats model; 2 EA could increase the frequency of open-arms entries （OE） and the duration of open-arms time （OT） in anxiety model rats. It could also increase OE% and OT% （ P 〈 0.05, or P 〈 0.01 ）. Conclusion： EA can decrease the anxiety level of CES model rats, so it has an obvious function of antianxiety.

关 键 词：电针 百会 三阴交 慢性情绪应激 焦虑模型 

分 类 号：R245.319[医药卫生—针灸推拿学]