D-二聚体和高敏C-反应蛋白及脑钠肽浓度测定对急性冠脉综合征预后的预测价值  

Predicting Values of D-dimer,High Sensitivity C Reactive Protein,and Brain Natriuretic Peptide Concentration Measurement in Prognosis of Acute Coronary Syndrome Patients

作　　者：宋予苹 王文君[1] 徐泽昌[1] 张银合[1] 

机构地区：[1]北京市健宫医院心内科,100054

出　　处：《中国全科医学》2007年第10期801-803,共3页Chinese General Practice

摘　　要：目的评估D-二聚体（D-dimer）、高敏C-反应蛋白（high sensitivity C reactive protein,hs-CRP）及脑钠肽（brain natriuretic peptide,BNP）对急性冠脉综合征（acute coronary syndrome,ACS）患者临床预后的预测价值。方法选择2004-2005年10月收入我院CCU确诊的ACS患者100例,于发病后即刻及24h清晨静脉采血,采血前避免高盐饮食,检测血D-dimer、hs-CRP及BNP水平。结果在住院期间和平均6个月的随访期内,有、无心血管事件再发组患者入院即刻及入院24h的血D-dimer、hs-CRP及BNP水平间差异均有显著性意义（P〈0.05）。结论检测D-dimer、BNP及hs-CRP水平对ACS患者的预后具有重要的预测价值。Objective To evaluate the clinical prediction values of D -dimer, high sensitivity C -reactive protein （ hs - CRP） and brain natriuretic peptide （BNP） in the prognosis of acute coronary syndrome （ACS） patients. Methods One hundred consecutive ACS patients aged between 40 and 75, admitted into CCU from January 2004 to October 2005, were included in this study. Venous blood was sampled immediately after the onset and in the early morning 24 hours later, The patients were in low - salt diet before blood sampling. The levels of Serum D - dimer, hs - CRP and BNP were measured. Results During the hospitalization period and the follow - up period （ 6 months on average）, there were significant differences in the levels of D - dimer, hs - CRP and BNP between the moment of onset and 24 h after hospitalization for patients with or without relapse of cardiovascular events （ P 〈 0. 05）. Conclusion Measuring the levels of D - dimer, hs - crp and BNP is of great significance in predicting the clinical prognosis of ACS patients.

关 键 词：D-二聚体 高敏C-反应蛋白 脑钠肽 急性冠脉综合征 预后 

分 类 号：R541.4[医药卫生—心血管疾病]