复方双黄溶液对重度烧伤大鼠肠黏膜损伤超微结构的影响  

The influence of Compound Shuanghuang liquor on the ultrastructure of intestional mucosa in the rats with severe burn

作　　者：段九梅[1] 贺立新[1] 孙志刚[1] 曹玉珏[1] 

机构地区：[1]北京医院协会右安门医院烧伤整形科,100069

出　　处：《中华损伤与修复杂志（电子版）》2007年第1期30-32,共3页Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)

摘　　要：目的探讨复方双黄(主要成份大黄和黄芪)溶液对重度烧伤后大鼠肠黏膜超微结构和作用机制。方法以大鼠为实验动物分为正常对照组不烫伤、自由进食水;烧伤对照组烧伤前1 h胃饲1 ml 生理盐水,烧伤后6 h 第2次胃饲,4 d;烧伤胃饲大黄组,烧伤胃饲双黄组在同等时间胃饲等量大黄溶液,复方双黄溶液。通过透射电镜、扫描电镜观察肠黏膜病理形态。结果烧伤胃饲双黄组肠黏膜病理形态改变较烧伤胃饲大黄明显减轻。结论复方双黄溶液可改善烧伤后肠黏膜病理形态改变,且优于烧伤胃饲大黄组。Objective To discuss the influence and mechanism of Compound ShuangHuangLian liquor on the ultrastructure of intestinal mucosa in the rats with severe burn. Methods The rats were randomly divided into three groups. The rats in normal control group were freely for food and water without scalding. The rats in scalded control group were orally administered lml 0.9% saline before the scalding for an hour, the same were orally administered lml 0.9% saline after the scalding for 6 hours, 4/d. For the rats in scalded with rhubarb liquor treatment and scalded with compound ShuangHuangLian liquor treatment group equal amount of rhubarb liquor and Compound ShuangHuangLian liquor were orally administered respectively at the same time. The pathological changes of intestinal mucosa were observed by the transmission electron microscope and the scanning electron microscope. Results The intestinal mucosa in scalded rats with compound ShuangHuang liquor treatment group exhibited less pathological changes than that with rhubarb liquor treatment group. Conelusions The Compound ShuangHuangLian liquor could improve the pathological changes of the intestinal mucosa in rats inflicted by severe scalding. And which was better than the rhubarb liquor.

关 键 词：烧伤 肠黏膜 大黄 复方双黄溶液 

分 类 号：R285.5[医药卫生—中药学]