布地奈德对鼻息肉中RANTES的影响  

Effect of budesonide on RANTES expression in nasal polyps

作　　者：朱华斌[1] 冯云海[1] 殷善开[1] 

机构地区：[1]上海交通大学附属第六人民医院耳鼻咽喉科,上海200233

出　　处：《中国耳鼻咽喉颅底外科杂志》2007年第2期103-105,共3页Chinese Journal of Otorhinolaryngology-skull Base Surgery

基　　金：上海市卫生局科研基金资助项目(024034)

摘　　要：目的观察鼻息肉组织中RANTES及嗜酸性粒细胞表达的变化,探讨糖皮质激素治疗鼻息肉的可能机制。方法对40例鼻息肉患者分别采用布地奈德1 mg或2 mg鼻腔雾化治疗,并以20例生理盐水治疗作为对照,通过免疫组化方法测定鼻息肉治疗前后的RANTES表达及嗜酸性粒细胞数量的变化。结果经布地奈德治疗后鼻息肉中RANTES的表达较治疗前显著降低(P<0.05),以布地奈德2 mg组为明显,且嗜酸性粒细胞也随之下降,二者有相关性;而对照组治疗前后差异无统计学意义(P>0.05)。结论RANTES是诱导嗜酸性粒细胞在鼻息肉中浸润的重要趋化因子,布地奈德可能通过下调RANTES的表达,发挥抗嗜酸性粒细胞炎症的作用。Objective To discuss the possible mechanism of glucocorticoids in the treatment of nasal polyps by detecting the changes of RANTES expression and the number of eosinophils. Methods 40 cases with nasal polyps were treated with atomization of nasal inhaled budesonide （1 mg or 2 mg） and 20 treated with normal saline were chosen as control. The expression of RANTES was detected by immunohistochemical technique and the number of eosinophils was counted before and after treatment. Results The expression of RANTES decreased after the treatment of budesonide （ P〈0. 05） and the changes in patients treated with 2 mg budesonide were more dramatic than those treated with 1 mg budesonide. Meanwhile, the number of eosinophils decreased correspondingly. The changes in the control group were statistically insignificant （ P〉0. 05）. Conclusion RANTES actively participate in the process of eosinophilic inflammation. Budesonide may present some anti-inflammatory effects by downregulating the expression of RANTES.

关 键 词：鼻息肉 RANTES 布地奈德 嗜酸性粒细胞 

分 类 号：R765[医药卫生—耳鼻咽喉科]