Kringle5的药理特性及其在眼科的应用  

Pharmacological properties of Kringle 5 and its application in ophthalmology

作　　者：陈媛[1] 刘祖国[1] 肖启国[1] 

机构地区：[1]南华大学第二附属医院眼科,湖南衡阳在读研究生421001

出　　处：《眼科研究》2007年第5期397-400,共4页Chinese Ophthalmic Research

摘　　要：Kringle5(K5)是人纤溶酶原的蛋白水解片断,是一种新近发现的血管增生抑制因子,经实验证明为抑制活性最强的纤溶酶原水解片段。它主要通过抑制内皮细胞增生、迁移,并诱导内皮细胞凋亡、细胞周期停止而发挥作用,也可减少血管渗漏,具有很强的抑制活性。K5生物活性高,特异性强,相对分子质量小,性质稳定,不良反应轻,在眼科领域显示良好的应用前景。就K5的药理特性及其在眼科的应用做一综述。Angiostatin, an internal fragment of plasminogen comprising the first four triple disulfide-linked kringle structure, has been documented to be one of the most potent endogenous angiogenesis inhibitors described to date. More recently, another kringle structure within plasminogen known as kringle 5 （ K5 ） was found. Plasminogen kringle 5, obtained as a proteolytic fragment of human plasminogen,is a novel endogenous angiogenesis inhibitor, furthermore,it displays more potent inhibitory, effect on angiogenesis than any other proteolytic fragment of human plasminogen. Kringle 5 of human plasminogen has been shown to anti angiogenesis by inhibition endothelial cell growth, migration, and induction of cell cycle arrest and the apoptosis of proliferating endothelial cell. Kringle 5 has higher biological activity, stronger specificity, lower molecular mass and few side effects. Accordingly, the application of Kringle 5 has therapeutic role in ophthalmology. The pharmacological properties of kringle 5 and its potential applications in ophthalmology are summarized in this article.

关 键 词：纤溶酶原 KRINGLE 5 血管增生 

分 类 号：R96[医药卫生—药理学]