Peptides radiolabeled with Re-186/188 and Tc-99m as potential diagnostic and therapeutic agents  

作　　者：E. GARCíA-GARAYOA R. SCHIBLI P.A. SCHUBIGER 

机构地区：[1]Center for Radiopharmaceutical Science of the ETH Zurich-Paul Scherrer Institut-University Hospital Zurich, CH-5232, Villigen PSI, Switzerland [2]Center for Radiopharmaceutical Science of the ETH Zurich-Paul Scherrer Institut-University Hospital Zurich, CH-5232, Villigen PSI, Switzerland Department of Chemistry and Applied Biosciences ETH Zurich, 8093 Zurich, Switzerland

出　　处：《Nuclear Science and Techniques》2007年第2期88-100,共13页核技术（英文）

摘　　要：Small peptide-based compounds have attracted an enormous interest as carrier molecules to selectively de- liver radionuclides to target tissues, sparing critical normal organs. When looking for "matched pairs" of radionuclides, suitable for radiolabeling of peptides for diagnosis and therapy, technetium and rhenium represent an almost ideal constellation. The important role of technetium-99m and Re-186/188 is based on the decay characteristics, suitable for tumor diagnosis and therapy. Tc-99m and Re-188 are readily available by either a 99Mo/99mTc or the 188W/188Re ra- dionuclide generator system. Furthermore, technetium and rhenium are chemically related and share structural as well as reactive similarities, which prompt an attractive "matched-pair" situation. This article shows an overview of 99mTc- and 186/188Re-radiolabeled peptides that have been tested for their potential use as imaging and therapeutic agents in oncological diseases.Small peptide-based compounds have attracted an enormous interest as carrier molecules to selectively deliver radionuclides to target tissues, sparing critical normal organs. When looking for ＂matched pairs＂ of radionuclides, suitable for radiolabeling of peptides for diagnosis and therapy, technetium and rhenium represent an almost ideal constellation. The important role of technetium-99m and Re-186/188 is based on the decay characteristics, suitable for tumor diagnosis and therapy. Tc-99m and Re-188 are readily available by either a ^99Mo/^99mTc or the ^188w/^188Re radionuclide generator system Furthermore, technetium and rhenium are chemically related and share structural as well as reactive similarities, which prompt an attractive ＂matched-pair＂ situation. This article shows an overview of ^99mTc- and ^186/188Re-radiolabeled peptides that have been tested for their potential use as imaging and therapeutic agents in oncological diseases.

关 键 词：放射性同位素标记肽类 铼186/188 锝99M 诊断药物 治疗药物 

分 类 号：R817[医药卫生—影像医学与核医学]