银杏内酯吸入剂对哮喘模型豚鼠气管嗜酸性粒细胞浸润的影响  

Effects of Ginkgolides Inhalation on Eosinophils Infiltration in Airway of Asthmatic Guinea Pig Model

作　　者：高建[1] 郜文[2] 成亮[1] 陈怡[1] 徐平湘[1] 宋爱丽[3] 唐玉[1] 

机构地区：[1]首都医科大学化学生物学与药学院,北京市100069 [2]首都医科大学药物研究所,北京市100069 [3]首都医科大学病理学系,北京市100069

出　　处：《中国药房》2007年第15期1132-1133,共2页China Pharmacy

摘　　要：目的:探讨银杏内酯吸入剂对哮喘模型豚鼠气道嗜酸性粒细胞浸润的影响。方法:将豚鼠随机分为7组,每组8只,分别为哮喘模型组,银杏内酯吸入剂低、中、高剂量组(剂量分别为5、10、20mg·kg-1),银杏内酯腹腔注射(ip)组(剂量为20mg·kg-1),地塞米松组(剂量为10mg·kg-1)和正常对照组,计数肺灌注液(BALF)和支气管中的嗜酸性粒细胞(EOS)数。结果:与正常对照组比较,模型组BALF中的EOS显著增多,银杏内酯吸入剂组可显著减少BALF和支气管中的EOS浸润数(P<0.05)。结论:银杏内酯吸入剂能对抗哮喘豚鼠气道嗜酸性粒细胞浸润,可作为治疗支气管哮喘的一种新方法。OBJECTIVE： To observe the effects of Ginkgolides inhalation on eosinophils infiltration in airway of asthmatic guinea pig model. METHODS： Guinea pigs were divided into seven groups（n = 8 in each group）： model group, ginkgolides inhalation low, medium and high dosage groups（5, 10, 20mg·kg^-1, respectively）, ginkgolides ip group （at a dosage of 20 mg·kg^-1）, Dexamethasone ip group （at a dosage of 10 mg·kg^-1）, normal control group. The eosinophils （EOS） in bronchoalveotar lavage fluid （BALF） and trachea were counted. RESULTS： As compared with normal control group, the number of EOS in BALF was significantly increased in model group, but that in BALF and trachea of the Ginkgolides inhalation group was significantly reduced（P〈0.05） .CONCLUSION： Ginkgolides inhalation can antagonize the infiltration of eosinophils in airway of asthmatic guinea pigs, and it can be used as a new therapy for bronchial asthma.

关 键 词：银杏内酯 吸入剂 支气管哮喘 嗜酸性粒细胞 

分 类 号：R965[医药卫生—药理学] R974.3[医药卫生—药学]