黄芩苷分散片的制备及质量控制  

Preparation and Quality Control of Baicalin Dispersible Tablets

作　　者：宋群亮[1] 张平[1,2] 夏源[3] 孙旭群[4] 夏泉[4] 

机构地区：[1]安徽医科大学药学院 [2]安徽医科大学第一附属医院药剂科,合肥市230022 [3]合肥恒星药物研究所 [4]安徽医科大学第一附属医院药剂科

出　　处：《中国药房》2007年第15期1144-1146,共3页China Pharmacy

摘　　要：目的:制备黄芩苷分散片并建立其质量控制方法。方法:以崩解时间为指标,采用正交设计试验对黄芩苷分散片的处方进行优化,并采用HPLC法测定其含量和溶出度。结果:优化处方为交联聚维酮40%、羧甲基淀粉钠6%和预胶化淀粉2%;按优化处方制备的黄芩苷分散片在3min内完全崩解,15min溶出度达到90%以上。结论:本制备工艺简单、可行;所制分散片崩解迅速、溶出度高。OBJECTIVE： To prepare Baicalin dispersible tablets and establish a quality control method for this preparation. METHODS： The formula of Baicalin dispersible tablets was optimized by orthogonal experiment with disintegrating time as index. The content and dissolution rate of the tablets were determined by HPLC, RESULTS： The optimized formula was as follows： the contents of crospovidone, sodium starch glycolate and amylum pregelatinisatum were 40%, 6% and 2%, respectively. The dispersible tablets prepared in accordance with the optimize formula could disintegrate completely within 3 minutes and its dissolution rate could reach beyond 90% in 15 minutes. CONCLUSION ： The preparation process is simple and feasible, and the prepared Baicalin dispersible tablets had a rapid disintegration and high dissolution rate.

关 键 词：黄芩苷 分散片 正交试验 含量测定 溶出度 

分 类 号：R283[医药卫生—中药学] R927.1[医药卫生—中医学]