止嗽颗粒成型辅料的筛选与工艺研究  

Screening of Formative Excipients for Cough Remedy Granules and Technique Study

作　　者：李奉勤[1] 范文成[1] 史冬霞[1] 苏平菊[1] 

机构地区：[1]石家庄以岭药业股份有限公司,石家庄市050035

出　　处：《中国药房》2007年第15期1150-1152,共3页China Pharmacy

摘　　要：目的:优选止嗽颗粒的成型辅料。方法:考察不同辅料对止嗽颗粒成型性、吸湿性和临界相对湿度的影响,并用综合评分法筛选出制备止嗽颗粒的最优辅料及处方组成。结果:制备止嗽颗粒的最优辅料为乳糖;最佳处方组成为4份喷雾粉与6份乳糖混合制粒。结论:本法所制颗粒成型性、溶解性好,且不易吸湿,较为理想。OBJECTIVE： To optimize the formative excipients for cough remedy granules. METHODS： Effects of different excipients on the formation, moisture absorption and relative critical humidity of cough remedy granules were examined, and the optimal excipients as well as formula were selected by adoption of the comprehensive scoring method. RESULTS： The optimal excipient for preparation of cough remedy granules was lactose, and the best formula compri.sed of 4 doses of spraying powder and 6 doses of lactose mixture. CONCLUSIONS： The cough remedy granules thus prepared is ideal： good in granularity, easy to dissolve and not liable to moisture absorption.

关 键 词：止嗽颗粒 成型辅料 工艺研充 

分 类 号：R974[医药卫生—药品] R283[医药卫生—药学]