肺缺血／再灌注损伤与程序性细胞死亡  

Pulmonary ischemia reperfusion injury and programmed cell death

作　　者：詹美俊[1] 张诗海[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院麻醉科,武汉430022

出　　处：《国际麻醉学与复苏杂志》2007年第2期129-131,共3页International Journal of Anesthesiology and Resuscitation

摘　　要：肺缺血／再灌注损伤（pulmonary ischemia reperfusion injury，PIRI）在临床工作中时有发生，并且后果非常严重。最近研究表明程序性细胞死亡（pmgmmmed cell death，PCD）在其中起着重要的作用。与细胞坏死一样，PCD对肺组织造成严重的危害。有效地预防PCD的发生，将会增加PIRI的治愈率。Pulmonary ischemia reperfusion injury often take place in cardiac surgery and lung transplantation, but its consequence is very serious. Lung tissue necrosis after prolonged ischemia is known to worsen lung function, which is believed to be due largely to adjacent tissue inflammation. Recent studies suggest that lung apoptosis following ischemia-reperfusion could be equally important in the development of post - operative lung dysfunction. A better understanding of lung apoptosis, as well as prevention from it, may help surgeon decrease the incidence rate of PIRI.

关 键 词：程序性细胞死亡(PCD) 坏死 肺 缺血/再灌注损伤(I/R) 

分 类 号：R563[医药卫生—呼吸系统]