利用Lotka-Volterra方程建立大脑发育中基因的调控网络  

Establishing the Gene Expression Regulatory Networks Based on Lotka-Volterra Equations During Brain Development

作　　者：郭波涛[1] 李辉智[2] 王文昌[1] 易东[1] 

机构地区：[1]第三军医大学卫生统计学教研室,400038 [2]西南政法大学刑侦系,400031

出　　处：《中国卫生统计》2007年第2期138-139,142,共3页Chinese Journal of Health Statistics

基　　金：国家自然基金资助(60371034)

摘　　要：目的构建脑发育过程中,基因表达的调控网络。方法根据GO数据库选择与发育有关的基因,应用种群动力学的观念,将Lotka-Volterra方程用于基因之间的调控关系的描述。结果得到每个基因表达的内禀增长率和所选基因之间的调控矩阵,并用图像可视化。结论Lotka-Volterra方程可作为描述调控网络的一种方法。Objective To describe gene regulatory networks during brain development. Methods Based on GO database , we selected 30 genes related brain development , and applied the Lotka-Volterra equations to model the regulatory networks from the population dynamics standpoints. Results We obtained regulatory matrix and intrinsic rate of natural increase from a simple soultion to Lotka-Volterra equations. Conclusion This model can be used to describe the gene expression regulatory networks.

关 键 词：基因调控网络 Lotka-Volterra方程 基因芯片 

分 类 号：R318.0[医药卫生—生物医学工程]