COX-2、Bcl-2基因蛋白在尖锐湿疣组织中的表达及意义  

The expression of COX-2 and Bcl-2 in condyloma acuminatum

作　　者：刘启真[1] 陈向敏[1] 叶晓蕾[2] 

机构地区：[1]温州医学院生物学实验教学中心,325035 [2]温州医学院环境与公共卫生学院,325035

出　　处：《浙江医学》2007年第4期303-304,320,共3页Zhejiang Medical Journal

基　　金：温州市科技局科研基金项目(No.S2001A30)

摘　　要：目的探讨环氧合酶-2(COX-2)、Bcl-2基因蛋白在尖锐湿疣组织中的表达及意义。方法采用免疫组化SP法对49例尖锐湿疣(CA)组织和26例正常宫颈组织进行COX-2、Bcl-2蛋白检测。结果COX-2、Bcl-2基因蛋白在尖锐湿疣组的表达率和阳性表达程度显著高于正常对照组(P<0.01),但未发现Cox-2与Bcl-2的表达相关(P>0.05)。结论COX-2、Bcl-2基因蛋白表达与CA的发生发展相关,CA的发病可能与Cox-2、Bcl-2基因的阳性表达程度有关。Objective To investigate the expressions of COX-2 and Bcl-2 in condyloma acuminatum （CA） and its clinical significance. Methods The expression of COX-2 and Bcl-2 was detected using immuohistochemical staining in 49 specimens of CA, 26 specimens of normal cervical tissue. Results The expressive rate and expressive degree of COX-2 and Bcl-2 in CA were significantly higher than those in normal cervical tissue （P〈O.005）, and the expression of COX-2 w＆s not related to Bcl-2 （P〉O.005）. Conclusion The expression of COX-2 and Bel-2 seems to be correlated with the occurrence of condyloma acuminatum.

关 键 词：尖锐湿疣 环氧合酶-2 BEL-2 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]