鸡喹乙醇中毒对血中自由基水平及抗氧化系统的影响  

The Effect of Olaquindox Poisioing on Free Radical and Anti-oxidative System in Chicken Blood

作　　者：高洪[1] 浦雪艳 彭辂[3] 彭洁[1] 

机构地区：[1]云南农业大学,云南昆明650201 [2]上海开拓者生物科技发展有限公司,上海浦东201203 [3]四川大学,四川成都610064

出　　处：《云南农业大学学报》2007年第3期396-400,共5页Journal of Yunnan Agricultural University

基　　金：云南省自然科学基金资助(2003C0049M)

摘　　要：对鸡喹乙醇中毒时,血中自由基(MDA)及抗氧化系统的变化进行了研究;艾维因鸡随机分为两组,正常对照组(Ⅰ组),饲喂基础日粮;喹乙醇处理组(Ⅱ组),饲喂基础日粮,且以15 mg喹乙醇/kg体重处理Ⅱ组,连续处理42 d,每天1次,Ⅰ,Ⅱ组每7 d采血1次,共采血6次,测定MDA及抗氧化系统各指标水平;结果:第2-6次Ⅱ组MDA水平明显高于Ⅰ组(P<0.05,P<0.01),而Ⅱ组T-AOC,GSH,T-SOD,CAT,GST,GSH-PX水平明显低于Ⅰ组(P<0.05,P<0.01)。第1次各指标在Ⅰ,Ⅱ组间无显著性差异(P>0.05)。鸡喹乙醇中毒时可引起血中自由基水平(MDA)明显升高,而抗氧化系统各指标水平明显下降。The changes of free radical （malondialdehyde, MDA） and anti-oxidative system in chicken blood during olaquindox poisoning were achieved. Aiweiyin chickens were divided randomly into 2 groups ： the chickens of Control group （ group Ⅰ ） were only fed on basic diet, and those of olaquindox - treated group （ group Ⅱ ） were administrated by 15 micrograms olaquindox per kilogram body weight besides being fed on basic diet, olaquindox was orally given once per day with total times, blood was sampled 6 times with once per 7 days for detection of MDA and anti-oxidative indexes. At the 2nd to 6th detection, MDA of group Ⅱ was significantly higher than that of group Ⅰ （P 〈 0. 05, P 〈 0. 01 ）, and all anti-oxidative indexes （ T - AOC, GSH, T - SOD, CAT, GST, GSH - PX） of group Ⅱ were remarkably lower than those of group Ⅰ （ P 〈 0. 05, P 〈 0.01, no differences existed in group Ⅰ and group Ⅱ at the 1 st detection （ P 〉 0. 05 ）. Chicken olaquindox poisoning can results in remarkable increase of blood MDA and significant decrease of anti-oxidation indexes.

关 键 词：鸡 喹乙醇中毒 自由基 抗氧化酶 影响 

分 类 号：S852.3[农业科学—基础兽医学]