两亲性大环多胺La(III)配合物的合成、表征及催化质粒DNA水解的研究  

Macrocyclic polyamine La(III) complexes: syntheses,characteristics,catalytic hydrolysis for plasmid DNA

作　　者：蒋宁[1] 向清祥[2] 王钦[2] 陈善勇[2] 林宏辉[1] 余孝其[2] 

机构地区：[1]四川大学生命科学学院,四川成都610064 [2]四川大学化学学院绿色化学与技术教育部重点实验室

出　　处：《化学研究与应用》2007年第5期539-542,共4页Chemical Research and Application

基　　金：国家自然科学基金资助项目(20372051;20471038;20572075);教育部新世纪优秀人才资助计划项目;教育部博士点专项基金资助项目;四川省青年科技基金资助项目

摘　　要：Novel macrocyclic polyamine La(III) complexes have been synthesized.The hydrolysis of plasmid DNA(pUC18) by macrocyclic polyamine La(III) complexes has been investigated by using agarose gel electrophoresis method.The results indicated that these La(III) complexes could effectively promote the cleavage of plasmid DNA(pUC18) at physiological pH and temperature.Novel maerocyelie polyamine La（Ⅲ） complexes have been synthesized. The hydrolysis of plasmid DNA （pUC18） by maerocyelie polyamine La（Ⅲ） complexes has been investigated by using agarose gel eleetrophoresis method. The results indicated that these La（Ⅲ） complexes could effectively promote the cleavage of plasmid DNA （pUC18） at physiological pH and temperature.

关 键 词：大环多胺 配合物 DNA水解裂解 

分 类 号：O641.4[理学—物理化学]