炎性细胞因子在慢性心力衰竭中的作用  

The Effect of Inflammatory Cytokines in Chronic Heart Failure

作　　者：李科慧[1] 刘唐威[1] 伍伟锋[1] 

机构地区：[1]广西医科大学第一附属医院心内科,南宁530021

出　　处：《医学综述》2007年第10期734-736,共3页Medical Recapitulate

摘　　要：心力衰竭的特征是心功能逐渐恶化。近年来,一些小的生物分子-细胞因子,如肿瘤坏死因子-α、白细胞介素1β、白细胞介素6、白细胞介素10、白细胞介素-18、核因子-κB、Fas配基、单核细胞趋化蛋白1、C-反应蛋白等在心力衰竭中的作用越来越引起人们的注意。很多研究表明,这些细胞因子加速了心力衰竭的进程,它们是心力衰竭患者死亡的独立预测因子。在这篇综述里,概述了在心力衰竭的发展过程中细胞因子的重要性、表达及其机制。The characteristic of heart failure is the gradually aggravation in heart function.. In recent years, the effect of some small biological molecules in heart failure including tumor necrosis factor-α, interleukin - 1β, interleukin -6, interleukin-10, interleukin- 18, nuclear factor kappa B, fas ligand, monocyte chemoattractant protein-1, C reactive protein and so on, are attracting more and more attention from people.. Many researches indicate that these cellular factors accelerate the development of heart failure and can be the independent predictors of mortality in patients with advanced heart failure. In this review,we summarized the importance,expression and mechanism of cytokines in the development and progression of heart failure.

关 键 词：炎性细胞因子 慢性心力衰竭 作用 

分 类 号：R541.61[医药卫生—心血管疾病]