调脂灵对高脂血症大鼠降脂作用的实验研究  

The Influence of Tiaozhiling on Experimental Hyperlipoidemia in Rats

作　　者：唐春萍[1] 郭姣[1] 陈红红[1] 杨超燕[1] 陈艳芬[1] 陈湛[1] 

机构地区：[1]广东药学院,广东广州510224

出　　处：《中国实验方剂学杂志》2007年第5期24-27,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广东省科技厅重点引导项目(2004B33001026)

摘　　要：目的:研究不同提取工艺调脂灵对高脂血症大鼠血脂水平的影响。方法:采用雄性SD大鼠,随机分为正常组、模型组、不同提取工艺的调脂灵组和阳性药物组。正常组喂普通饲料,模型组喂普通饲料并给予脂肪乳剂灌胃(10 mL.kg-1)、调脂灵组给予脂肪乳剂灌胃(10 mL.kg-1)并隔4 h后灌胃给予相应的药物。观察动物的一般情况和血清甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和肝脏TG,TC的变化,并观察肝脏病变。结果:大鼠灌高脂乳剂14 d后,模型组大鼠TC,TG,LDL-C均较正常组明显升高,而不同工艺的调脂灵组均低于模型组,其中调脂灵水提组和综合提组与模型组比较血脂水平均有明显差异,但调脂灵水提组和综合提组之间无明显差别;模型组所有动物以及调脂灵90%醇提液、70%醇提液组动物肝脏的颜色偏黄,质地偏硬,肝脏表面有白点,其余各组大鼠肝脏颜色鲜红,质地偏软,有弹性,无病变迹象。结论:调脂灵水提液和综合提取液对高脂血症大鼠具有降脂作用,并以此结合化学检测作为筛选工艺的依据。Objective： To observe the influence of Tiaozhiling on experimental Hyperlipidemia of rats, and compare the effects of Tiaozhiling extracted with different techniques. Methods： SD male rats were randomly divided into four groups, normal group, hyperlipidemia model group, treated group and positive group. The general situation was observed and changes of TG, TC, LDL-C, HDL-C level in both blood serum and liver were tested. Results： Mter 14 days, the TG, TC, LDL-C levels of model group are much higher than the normal group. Compared with the model group,the TG, TC, LDL-C levels of the treated group are lower. The livers of all animals of the model group and some treated group are stiffer, and the color showed canary yellow. Conclusion. Both the water extracting and the mixed extracting Tiaozhiling are effective in decreasing the TC, TG, LDL-C levels of the experimental hyperlipidemia in rats. These results and chemical analysis provide the evidence for selecting different extracting techniques.

关 键 词：调脂灵 提取工艺 高脂血症 

分 类 号：R285.5[医药卫生—中药学]