双氢青蒿素哌喹对约氏疟原虫感染小鼠体内原虫消长的影响  

Study on the Effect of Dihydroartemisinin Piperaquine on Protozoan in Mice Infected with Plasmodium Yoelii

作　　者：刘向东[1] 张勇[2] 赵志刚[3] 唐红炜[1] 

机构地区：[1]河北北方学院寄生虫学教研室,河北张家口075000 [2]河北北方学院第一临床医学院,河北张家口075000 [3]张家口教育学院基础医学部解剖教研室,河北张家口075000

出　　处：《河北北方学院学报（医学版）》2007年第2期31-32,共2页Journal of Hebei North University:Medical Edition

摘　　要：目的:研究双氢青蒿素哌喹对约氏疟原虫感染小鼠红细胞感染率变化的影响。方法:用约氏疟原虫感染小鼠,于感染后第3天开始,连续3d口服双氢青蒿素哌喹20mg/kg,于感染后第2天开始每天观察其红细胞感染情况并计算感染率。结果:约氏疟原虫感染后,小鼠红细胞感染率逐渐上升。应用双氢青蒿素哌喹治疗后,红细胞感染率明显降低,与未治疗组相比差异显著(P<0.05)。结论:从原虫血症的变化上证明双氢青蒿素哌喹具有确切的抗疟效果。Objective： To study the effects and changes of protozoan applying Dihydroartemisinin piperaquine in treating the mice infected with Plasrnodiurn yoelii. Methods：The mice with malaria parasite were treated with Dihydroartemisinin piperaquine at single oral doses of 20mg/kg on the 3d after infection. The infection rate of RBC was observed every day from the second day after infection. Results：Infection of Plasrnodiurn yoelii causes the infective rate of RBC in the mice to increase gradually. Applying Dihydroartemisinin piperaquine contributed to the gradual decrease of the infective rate of RBC（P〈0.05）. Conclusion： It is proved that Dihydroartemisinin piperaquine has exact curative effect of on the changes of parasitemia.

关 键 词：双氢青蒿素哌喹 约氏疟原虫 小鼠 

分 类 号：R531[医药卫生—内科学]