醛固酮与糖尿病及其慢性并发症的关系  

Relationship between aldosterone and diabetes mellitus and its chronic complications

作　　者：王霞娟[1] 卜瑞芳[1] 邓振霞[1] 

机构地区：[1]南京医科大学附属无锡一院内分泌科,江苏无锡214002

出　　处：《医学研究生学报》2007年第5期548-552,共5页Journal of Medical Postgraduates

基　　金：南京医科大学发展基金资助项目(批准号:NY04059)

摘　　要：醛固酮合成酶基因(CYP11B2)部分位点的多态性改变除导致血浆醛固酮水平发生改变外,还与血糖变化密切相关。作者除对醛固酮传统的水钠滞留导致容量性血压升高外,还参与或介导了血管紧张素Ⅱ的部分靶器官损伤作用,与糖尿病及其慢性并发症的发生和进展有关作一综述,并对醛固酮受体拮抗剂在糖尿病慢性并发症中的治疗意义进行了分析与讨论。Several genetic polymorphisms of the aldosterone synthase gene （CYP11B2）, which may influence the plasma aldosterone levels, had been reported to influence the blood glucose levels. In addition to the effects of sodium （ and consequently water） resorption and potassium excretion, aldosterone could be involved in the development and progression of diabetes and its chronic complications. This paper also discussed the therapeutic significance of aldosterone receptor antagonists on the occcurance of chronic diabetic complications.

关 键 词：醛固酮 醛固酮受体拮抗剂 糖尿病 慢性并发症 

分 类 号：R587.1[医药卫生—内分泌]