食管癌组织中血管内皮生长因子的表达对树突状细胞的影响  

The effects of vascular endothelial growth factor on dendritic cells in esophageal tumor tissue

作　　者：杨文锋[1] 李道堂[1] 李静[1] 陈绪霞[1] 王善政[2] 

机构地区：[1]山东省肿瘤医院胸外科,山东济南250117 [2]山东大学齐鲁医院胸外科,山东济南250012

出　　处：《细胞与分子免疫学杂志》2007年第1期46-47,55,共3页Chinese Journal of Cellular and Molecular Immunology

摘　　要：目的:研究食管癌组织中血管内皮生长因子(VEGF)的表达对树突状细胞(DC)的影响。方法:对94例食管癌组织采用辣根过氧化物酶(HRP)标记的链霉亲和素-生物素法(LSAB),分别检测VEGF、S100蛋白的表达水平,并分析VEGF与S100+DC的相关性。结果:食管癌组织中VEGF的表达率为74.46%(70/94),VEGF的表达与患者的临床分期及癌组织的分化呈正相关(r=0.864,0.803,P<0.05)。临床分期越晚,病癌组织的分化越低,癌组织内S100+DC的密度越小(r=-0.763,-0.908,P<0.05)。随着癌组织内VEGF表达量的上升,S-100+DC的密度降低,二者呈负相关(r=-0.817,P<0.05)。结论:食管癌组织中VEGF的表达可降低S100+DC的密度,从而影响机体的免疫功能。AIM： To investigate the relationship between vascular endothelial growth factor （VEGF） and S100 protein positive dendritic cell （DC） in esophagelal tumor tissue. METHODS： VEGF and S100 protein in 94 patients with esophageal carcinoma were detected by HRP Labelled streptavidin biotin （ LSAB ） immunohistochemical method. RESULTS： Postive rate of VEGF in esophageal tumor tissues was 74.46% （70/94） ; and the later the clinical stage and the lower the differentiation level was the more VEGF was（ r= 0. 864, 0. 803, respectively; P〈0.05） ; while the later the clinical stage and the lower the differentiation level was, the less number of S100^＋ DCs existed （ r =- 0. 763, - 0.908, respectively; P 〈 0.05）. Furthermore, there was a reverse correlation between the expression of VEGF and S100^＋ DC （ r=- 0. 817, P 〈 0.05）. CONCLUSION： There may be a reverse relationship between the expression of VEGF and S100^＋ DC in esophageal tumor tissue, VEGF could decrease the number of S100^＋ DC and impair the immunological function of the body.

关 键 词：食管肿瘤 血管内皮生长因子 树突状细胞 S100蛋白 

分 类 号：R392.9[医药卫生—免疫学]