骨髓干细胞动员在深静脉血栓溶解中的作用  

Effect of bone marrow stem cell mobilization in resolusion of deep vein thrombosis

作　　者：陈以宽[1] 龚建平[1] 罗文军[1] 孙建民[1] 

机构地区：[1]重庆医科大学附属第二医院普外科,重庆400010

出　　处：《重庆医科大学学报》2007年第6期626-628,共3页Journal of Chongqing Medical University

摘　　要：目的:探讨骨髓干细胞动员在深静脉血栓溶解中的作用。方法:SD成年大鼠随机分为正常组、假手术组、手术组、动员组(使用rhG-CSF皮下注射)。分析不同时点外周血单个核细胞计数、病理组织形态、血栓机化率的变化。结果:动员组外周血单个核细胞计数明显升高,其余各组无明显变化。与手术组比较,术后第7天动员组静脉血栓内炎性细胞数量明显增多,第14天,血栓的机化范围更广,血栓机化率有显著性差异。结论:骨髓干细胞动员促进了血栓的溶解、吸收过程。Objective：To explore the effect of bone marrow stem cell mobilization in resolution of deep vein thrombosis.Methods：The SD adult rats were randomly divided into normal,sham,surgical and mobilization group （with subcutaneous injection of rhG-CSF）.The peripheral blood mononuclear cell count,pathological change and thrombus organization rate in different time were examined.Resets：The peripheral blood mononuclear cell count in mobilization group was significantly elevated, and there was no significant change in other groups.Compared with surgical group,there were more inflammatory cells in thrombus of mobilization group at 7th postoperative day,and the organization area of thrombus was wider and the organization rate was significantly different in mobilization group at 14th postoperative day （P〈0.05）.Conclusion：The bone marrow stem cell mobilization contribute to the resolution of deep vein thrombosis.

关 键 词：深静脉血栓 骨髓干细胞动员 集落刺激因子 

分 类 号：R654.4[医药卫生—外科学]