α-SMA、TGFβ1在尿道下裂阴茎下弯组织中的表达及意义  

α-SMA,TGFβ1 in tissues on the surface of cavernosa of ventral penis with penile ventral curvature

作　　者：李浪[1] 魏光辉[1] 刘星[1] 张德迎[1] 张超[1] 

机构地区：[1]重庆医科大学儿童医院泌尿外科,重庆400014

出　　处：《重庆医科大学学报》2007年第6期635-637,共3页Journal of Chongqing Medical University

摘　　要：目的:探讨尿道下裂阴茎下弯畸形阴茎海绵体腹侧表面组织病理学特点,认识尿道下裂阴茎下弯形成机制,为临床治疗方案提供一定的依据。方法:以尿道下裂伴阴茎下弯23例为研究对象,3例隐匿性阴茎手术病例为对照组和3例躯体瘢痕病例,应用免疫组织化学SABC检测组织中α-SMA、TGFβ1的阳性表达情况。结果:尿道下裂组和瘢痕组α-SMA、TGFβ1表达强度均较对照组明显升高,存在统计学差异(P<0.05);尿道下裂轻度、中度及重度下弯三组之间无显著性差异。结论:尿道下裂并发阴茎下弯者,其阴茎海绵体腹侧表面及尿道板下组织为纤维索带,可能是阴茎下弯形成的病理学基础。Objective：To evaluate the pathological characteristics of tissues on the surface of cavernosa of ventral penis with ventral curvature and to investigate the etiology of congenital ventral curved hypospadias.Methods： α-smooth musle actin （α-SMA） ,transforming growth factor β 1 （TGF β 1 ） in tissue sections of 23cases of hypospadias with penile ventral curvature, 3 concealed penis and 3 somatic scar were detected by immunohistochemical method of SABC.Result：The expressions of α -SMA ,TGF β 1 in hypospadic ventral areas were markedly higher than those in normal and scar tissues （P〈0.05）.Conclusions： Rich fibrous tissues are present in the hypospadic specimens analysed, which possibly contributes to penile curvature of hypospadias.

关 键 词：尿道下裂 阴茎下弯 Α-平滑肌动蛋白 转化生长因子Β1 

分 类 号：R726.9[医药卫生—儿科]