川芎嗪对癫痫模型海马内信号分子的影响  

The Effect of Tetramethylpyrazine on Epilepsy Model of Signaling Molecule in Hippocampus of Rats

作　　者：朱晓琴[1] 雷水生[1] 

机构地区：[1]咸宁学院医学院,湖北咸宁437100

出　　处：《河南中医学院学报》2007年第3期15-16,共2页Journal of Henan University of Chinese Medicine

基　　金：湖北省自然科学基金资助项目(编号:B200528001)

摘　　要：目的:研究戊四氮(pentylenetetrazol,PTZ)点燃癫痫模型大鼠海马内环磷腺苷(Cyclic Adenosine monophosphate,cAMP)、环-磷酸鸟苷(cyclic guanosine monophosphate,cGMP)的变化及川芎嗪(Tetramethylpyrazine,TMP)对其的影响。方法:将实验动物随机分为3组,正常对照组、癫痫模型组、TMP治疗组。采用放射免疫法测定海马内cAMP、cGMP的含量。结果:模型组与正常对照组比,cAMP、cGMP含量明显增加,cAMP/cGMP比值明显减小,差异均具有显著性意义(P<0.01),TMP治疗组与癫痫模型组比,cAMP含量明显增加,cGMP含量则明显减少,cAMP/cGMP比值明显增加,差异均具有显著性意义(P<0.01)。结论:川芎嗪抑制癫痫放电作用与其调节海马内cAMP、cGMP含量变化有关。Objective： To study the effect of tetmmethylpyrazine （TMP） in treating epilepsy and its relation to signaling molecule in hippocampus of rats. Methods： Experimental animal were selected and randomized into three groups： normal saline control group, pentylenetetrazol group and treatment of tetramethylpyrazine group, and the changes of the content of cAMP, cGMP in hippocampus of rats were detected using radioimmunity method. Results： The content of the cAMP, cGMP in hippocampus in pentylenetetrazol groups were significantly higher than in those saline control groups. While the proportionality in pentylenetetrazol groups were significantly lower than in saline control groups （P 〈 0.05）. The content of cAMP in hippocampus in those intreatment of tetramethylpyrazine groups were significantly higher than those in pentylenetetrazol groups. While the content of the cGMP in hippocampus in intreatment of tetramethylpyrazine groups were significantly lower than in those pentylenetetrazol groups （P 〈 0.05）. The proportionality in pentylenetetrazol groups were significantly higher than in saline control groups （P〈 0.05）. Conclusion： Tetramethylpyrazine inhibit epilepsy discharge may be its regulation the content of cAMP, cGMP in hippocampus.

关 键 词：川芎嗪 海马 癫痫 环-磷酸腺苷 环-磷酸鸟苷 放射免疫 

分 类 号：R285.5[医药卫生—中药学]