双黄连注射剂致过敏性休克流行病学特点  

Epidemiological characteristic of anaphylactic shock caused by Shuanghuanglian Injection

作　　者：吴嘉瑞[1] 张冰[1] 

机构地区：[1]北京中医药大学,北京100102

出　　处：《中成药》2007年第5期638-641,共4页Chinese Traditional Patent Medicine

基　　金：国家食品药品监督管理局药品评价中心项目(2005B0601)

摘　　要：目的：探讨双黄连注射剂引起过敏性休克的流行病学特点与诱发因素。方法：通过检索1978～2005年医药学期刊,收集双黄连注射剂致过敏性休克病案72例,应用文献计量学方法对病案的流行病学资料进行分析。结果：资料中,18～44岁的青年患者比例最高（46.48%）;男性37例（52.11%）,女性34例（47.89%）;患者原发疾病中上呼吸道感染比例最高（68.75%）;过敏性休克多发生在给药30 m in内（89.36%）;7例患者抢救无效死亡,死亡率9.72%。结论：双黄连注射剂可引起较严重的甚至危及生命的过敏性休克,其发生机制涉及患者体质等多方面因素。AIM： To investigate the epidemiological characteristic and causative factors of anaphylactic shock caused by Shuanghuanglian Injection （Flos Lonicerae Japonicae, Radix Scuteilariae, Fructus forsythiae）. METHODS ： Domestic medicine periodicals were searched between 1978 and 2005, and 72 cases with anaphylactic shock caused by Shuanghuanglian Injection were analysed by literature metrologic method. RESULTS： There were large proportion of young sufferers from age 18 to 44 in the case reports, and male 52.11%, female 47.89% , the primary affections were mainly upper respiratory tract infection, the occurrence of ADRs was commonly within 30 mins after injection, seven patients died of the terrible anaphylactic shock. CONCLUSION： Shuanghuanglian Injection may induce dangerous, even fatal anaphylactic shock, its mechanism includes many factors, such as patient＇s physical constitution.

关 键 词：双黄连注射剂 过敏性休克 不良反应 

分 类 号：R287[医药卫生—中药学]