薯蓣皂苷元对灌胃FT-207荷瘤小鼠的减毒作用  

Attenuation of diosgenin on FT-207 in tumor-bearing mice

作　　者：李会影[1] 李光子[1] 阴景峰 贲彦鸿[1] 陈声武[1] 

机构地区：[1]吉林天药科技有限公司,吉林长春130012

出　　处：《中成药》2007年第5期655-658,共4页Chinese Traditional Patent Medicine

摘　　要：目的:研究薯蓣皂苷元(D iosgen in,D io)对替加氟(FT-207)抗肿瘤的增效减毒作用。方法:以小鼠MFC,HepA,H22和S180移植性肿瘤为模型测定其抑瘤率、生命延长率及荷瘤小鼠的免疫功能。结果:薯蓣皂苷元对小鼠MFC有明显的抑瘤作用,能提高巨噬细胞的功能,血清溶血素的含量。结论:薯蓣皂苷元可增加替加氟的抑瘤效果,提高机体免疫功能,减轻化疗毒副反应。AIM： To observe the effects of diosgenin on enhancing efficacy and reducing toxicity of FT-207 in tumor-bearing mice. METHODS： The inhibitory rate on tumor growth and immune function of the in tumor-bearing mice model of transplanting MFC,HepA, H22 and S180 tumor were measured. RESULTS： Diosgenin had significant restraining effects on MFC in mouse. It could enhance the activity of macrophage and the level of serum hemolysin. CONCLUSION： Diosgenin can enhance the anti-tumor effect of FT-207. It can also improve the immunological function and reduce the adverse reactions of chemotherapy.

关 键 词：薯蓣皂苷元 替加氟 荷瘤小鼠 增效减毒 

分 类 号：R285.6[医药卫生—中药学]