风湿马钱片药物配伍规律的研究  

Compatible regularity of Fengshi Maqian Tablet

作　　者：王胜春[1] 瞿新红[1] 李剑峰[1] 刘明义[1] 

机构地区：[1]第四军医大学西京医院药剂科,陕西西安710032

出　　处：《中成药》2007年第5期658-663,共6页Chinese Traditional Patent Medicine

摘　　要：目的:研究风湿马钱片配伍对主要化学成分,药效作用的影响,综合分析该方的配伍规律。方法:采用5因素2水平正交互交设计,HPLC法测定各配伍组主要成分,肉芽肿和耳肿胀抗炎实验检测配伍组药效作用。结果:各配伍组合中,ABD(马钱子+僵蚕+麻黄+全蝎+苍术+甘草),E(乳香+没药)这两个配伍组对小鼠肉芽肿和耳肿胀均有抑制作用。其中,对肉芽肿的抑制作用顺序为E>ABD;对耳肿胀的抑制作用顺序为ABD>E。结论:试验初步显示风湿马钱片方中臣、佐、使药对君药马钱子作用与毒性有着显著影响。AIM ： To investigate the influence of compatibitity in Fengshi Maqian Tablet [ ABD group （ Semen strychni, Bombyx batryticatus, Herba ephedrae, Scorpio, Rhizoma atractylodis, Radix et Rhizoma glycyrrhizae） E group （ Olibanum; Myrrha） ]. METHODS ： In the use of orthogonal design （5 factors and 2 levels）. HPLC method were used to determine the main chemical componets such as strychnine, brucine and ephedrine. And anti-inflammation was adopted as pharmacological experiment. RESULTS： In the inhibitive experiment of granuloma, ABD group was superb to E group. In the tumescence experiment, otherwise. CONCLUSION： The minister, assistant and guide herbs in Fengshi Maqian Prescription had a significant effect on the toxicity of monarch medicines-Semen strychni.

关 键 词：风湿马钱片 配伍 马钱子 

分 类 号：R285.6[医药卫生—中药学]