不饱和聚磷酸酯/β-磷酸钙复合材料的体外降解性能  

In Vitro Degradation Properties of Unsaturated Polyphosphoester/β-Tricalcium Phosphate Composites

作　　者：包瑞[1] 刘承美[1] 许燕[1] 莫健华[2] 邱进俊[1] 

机构地区：[1]华中科技大学化学系 [2]华中科技大学塑性成形模拟及模具技术国家重点实验室,湖北武汉430074

出　　处：《高分子材料科学与工程》2007年第3期223-227,共5页Polymer Materials Science & Engineering

基　　金：湖北省创新群体研究基金(2004ABC001)资助项目

摘　　要：研究了不饱和聚磷酸酯(UPPE)、N-乙烯基吡咯烷酮(NVP)与β-磷酸钙(β-TCP)交联复合体系的体外降解过程,并用扫描电镜观察了降解一定时间后试样表面的形貌结构。结果表明:UPPE/NVP/β-TCP交联复合材料具有可降解性,并能在降解过程中保持接近人体松质骨的力学强度,其表面为多孔“蜂窝”状,利于成骨细胞的粘附。降解初期,由于体系中聚乙烯基吡咯烷酮(PVP)、NVP的快速溶出,试样的质量、力学强度等物理性质变化明显;降解48 h之后,交联网络逐渐发生降解断链,各物理性质平稳变化。The in vitro degradation of the crosslinked composites formed by unsaturated polyphosphoester （UPPE）. N-vinyl pyrrolidone （NVP） and β-tricalcium phosphate （β-TCP） was investigated and the surface morphology of dagradation sample was imaged by scanning electron microscopy （SEM）. The results indicate that the UPPE/NVP/β-TCP crosslinked composite is degradable in simulated body fluid. The mechanical property of degradation sample is close to that of human cancellous bone, and the surface of degradation sample exhibits porous morphology after degradation, which will benefit the attachment and growth of the osteoblast cells. The physical parameters（sample mass, mechanical property, et al. ） changed dramatically during the initial stages of degradation. After 48 h of degradation, the physical parameters changed gradually due to the slow degradation of the crosslinked networks.

关 键 词：不饱和聚磷酸酯 生物高分子 骨组织工程支架材料 复合材料 体外降解 

分 类 号：TB332[一般工业技术—材料科学与工程]