室间隔缺损封堵术对心脏重构近、中期的影响  

Short and mid-term effects of percutanous transcatheter closure of ventricular septal defects on the cardiac remodeling

作　　者：郑昭芬[1] 蒲晓群[1] 杨天崙[1] 陈晓彬[1] 李传昶[1] 莫龙[1] 张利辉[1] 谢伟[1] 邓金华[1] 

机构地区：[1]中南大学湘雅医院心血管内科,长沙410008

出　　处：《中南大学学报（医学版）》2007年第2期320-322,共3页Journal of Central South University ：Medical Science

摘　　要：目的:应用超声心动图评价室间隔缺损封堵术后心脏结构与大小的近、中期变化。方法:观察30例室间隔缺损患者封堵术前、术后第3天,术后3个月和术后6个月左室舒张末期内径(LVEDD)、左室舒张末期容积(LVEDV)、左房内径(LAd)和右室内径(RVd)大小及变化。结果:封堵术后第3天,LVEDD与LVEDV较术前缩小,术后3个月、术后6个月随访时,LVEDD与LVEDV进一步缩小。封堵术后3个月、术后6个月,LAd较术前缩小,术后6个月与术后3个月比较无明显变化。术后第3天RVd较术前增大,术后3个月、术后6个月与术前比较无明显差异。结论:经导管室间隔缺损封堵术能有效改善室间隔缺损患者近、中期心脏重构。Objective To evaluate the short and mid-term changes of the cardiac morphology after percutanous transcatheter closure of ventricular septal defects （VSD） with transthoracic echocardiography （TIE）. Methods The left ventricular end-diastolic diameter （LVEDD）, left ventricular end-diastolic volume （LVEDV）, left atrial diameter （LAd）, and right ventricular diameter （RVd） in 30 VSD patients were measured before the VSD closure, and on the 3rd day, 3rd month, and 6th month after the VSD closure by rITE. Results LVEDD and LVEDV significantly decreased on the 3rd day after the VSD closure compared with pre-VSD closure. LVEDD and LVEDV continuously decreased on the 3rd month and 6th month after the VSD closure. LAd was smaller on the 3rd month and 6th month after the VSD closure, but there was not significant difference between the 3rd and 6th month. RVd increased on the 3rd day after the VSD closure, while no significant difference was found among the 3rd month and 6th month before and after VSD closure. Conclusion Percutanous transcatheter VSD closure may effectively improve the cardiac remodeling in VSD patients in the short and mid-term follow-up.

关 键 词：室间隔缺损 经导管关闭 心脏重构 近、中期疗效 超声心动图 

分 类 号：R541.1[医药卫生—心血管疾病]