母源抗体对同源及异源禽网状内皮增生病病毒感染诱发免疫抑制的预防作用  

Comparisons of Preventive Effects of Maternal Antibody on Immunosuppression Induced by Homologous and Heterologous Reticuloendotheliosis Viruses

作　　者：孙淑红[1] 崔治中[1] 孙爱军[1] 朱秀同[1] 

机构地区：[1]山东农业大学动物科技学院,泰安271018

出　　处：《畜牧兽医学报》2007年第5期488-492,共5页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家自然科学基金重点项目(#30330450);山东省科技厅项目(#011020102)资助

摘　　要：蛋用型海兰褐母鸡在用网状内皮增生病病毒(REV)细胞适应毒REV-C99(p30)免疫接种后,均在2周内产生REV特异性抗体。来自免疫种鸡的雏鸡在7日龄内100%(10/10)REV母源抗体阳性。分别在有母源抗体和没有母源抗体的1日龄鸡接种与疫苗株同源的低传代毒REV-C99(p3)或异源的REV中国野毒株HA9901(p5),以此比较母源抗体对同源和异源REV病毒感染造成的免疫抑制的预防作用。结果表明,REV母源抗体能同等有效地预防同源和异源REV感染造成的对H5和H9禽流感灭活疫苗HI抗体反应的抑制作用。Egg-type Hyline breeders were vaccinated with cell-adapted reticuloendotheliosis virus （REV） strain REV-C99（p30）, all chickens became REV-antibody positive 2 weeks after vaccination. And all chicks （10/10） from vaccinated breeders were REV-maternal antibody positive within 7 days after hatch. To compare preventive effects of maternal antibody on immunosuppression induced by homologous and heterologous REV, both REV-maternal antibody positive and negative chicks were inoculated with homologous strain REV-C99（p3） of low passage and heterologous REV field stain HA9901. The results indicated that REV-specific maternal antibody was able to effectively prevent immunosuppression induced by homologous or heterologous REV strains as the hemagglutinatin inhibition antibody titers were compared after vaccination with inactivated vaccines against H5 and H9 avian influenza viruses.

关 键 词：网状内皮增生病病毒 母源抗体 免疫抑制 禽流感疫苗 

分 类 号：S858.315.3[农业科学—临床兽医学]