复方美沙芬颗粒对枸橼酸引咳豚鼠镇咳及对蟾蜍食管纤毛运动的作用  

Effect of compound dextromethorphan granules on cough-relieving in guinea pigs and on the movement of esophageal cilia in toads

作　　者：刘昌发[1] 冯国清[2] 付润芳[2] 张卫[1] 徐宏平[1] 齐赤虹 

机构地区：[1]郑州铁路职业技术学院药学系,郑州450052 [2]郑州大学基础医学院药理学教研室,郑州450001 [3]河南省医药学校,开封475001

出　　处：《郑州大学学报（医学版）》2007年第3期528-530,共3页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的观察复方美沙芬颗粒对枸橼酸引咳豚鼠的镇咳作用及对蟾蜍食管纤毛运动的作用。方法①以175g/L枸橼酸喷雾制作豚鼠咳嗽模型,观察咳必清和复方美沙芬颗粒(53.6mg/kg,26.8mg/kg,13.4mg/kg3个剂量组)的镇咳作用。②以蟾蜍食管纤毛运动为指标,观察异丙肾上腺素和复方美沙芬颗粒(17.376mg/L,8.688mg/L,4.344mg/L3个剂量组)对蟾蜍食管纤毛运动速度的影响。结果①复方美沙芬各剂量组均可显著减少枸橼酸诱发的咳嗽模型的咳嗽次数(P<0.05),中剂量组镇咳效果最佳,且作用强于咳必清。②各剂量组均能显著加快蟾蜍食管纤毛运动的速度,与异丙肾上腺素相比,中剂量组加快纤毛运动的作用更加显著(P<0.05)。结论复方美沙芬颗粒具有显著镇咳、祛痰作用,中剂量组效果最佳。Aim ： To observe the effect of compound dextromethorphan granules on cough-relieving in guinea pigs and on the esophageal cilia movement in toads. Methods：The guinea pig cough model was established by 175 g/L citric acid spray. The cough reliving effects of pentoxyverine and compound dextromethorphan granules at 3 doses （53.6 mg/kg, 26. 8 mg/kg and 13.4 mg/kg） were observed; the effects of isoproterenol and compound dextromethorphan granules at 3 doses （17. 376 mg/L,8. 688 mg/L,4. 344 mg/L） on the movement speed of esophageal cilia in toads were observed. Results： Every dose group of compound dextromethorphan granules could reduce the cough times significantly（ P 〈 0.05 ） and increase the swing speed of esophageal cilia in toads. Compared with positive control, the maiddle-dose group of compound dextromethorphan granules had more prominent effect（ P 〈 0.05 ）. Conclusion ： Compound dextromethorphan granules have marked effects on cough-relieving and sputum-removing.

关 键 词：复方美沙芬 镇咳 纤毛运动 豚鼠 蟾蜍 

分 类 号：R974[医药卫生—药品]