NIDDM病人红细胞变形能力与膜收缩蛋白关系的研究  

A study on the relation between erythrocyte deformability and spectrin in patients with NIDDM

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作  者:刘成玉[1,2,3] 曲彦[1,2,3] 王秀丽[1,2,3] 谭润鸾[1,2,3] 

机构地区:[1]青岛医学院诊断学教研室 [2]青岛市市立医院 [3]青岛医学院生物化学教研室

出  处:《中国糖尿病杂志》1997年第1期26-28,共3页Chinese Journal of Diabetes

摘  要:检测了72例NIDDM病人红细胞变形能力(ED)和红细胞膜收缩蛋白二聚体(SP-D)和四聚体(SP-T)相对含量的变化,以探讨膜收缩蛋白对ED的影响。结果显示,NIDDM病人红细胞滤过指数(IF)明显高于对照组(P<0.00I),有血管病变者增高更明显:NIDDM病人红细胞膜SP-D和SP-D/SP-T明显增高,SP-T明显减低,与对照组比较有显著性差异(P<0.001),有血管病变者变化较无血管嵅”In order to study the relatinn between erythrocyte deformability (ED) and spectrin , the ED and spectrin dimers (SP-D) and spectrin tetramers (SP-T) were measured in 72 patients with non-in- sulin dependent diabetes mellitus (NIDDM ) . The results showed that erythrocyte filtration index (IF ) was markedly higher in patients than that in controls ( P <0. 001 ) , the increase of IF was more obvious in patients with angiopathy than that in patients withottt ( P <0. 001 ) . The SP-D and SP-D/SP-T were markedly higher , the SP-T was lower in patient. than that in controls . P <0. 001 ) , these changes were more obvious in patients with angiopathy than that in patients without ( P < 0. 001 ). In NIDDM pa- tients , the erythrocyte IF was positively correlated to SP-D and SP-D/SP-T ( P < 0. 001 ) , but there was a negative correlation between IF and SP-T ( P <0. 001 ). These results indicated that the decrease of ED in NIDDM patient. might he closely related to the abnormalities of erythrocyte spectrin.

关 键 词:糖尿病 红细胞变形能力 膜收缩蛋白类 

分 类 号:R587.102[医药卫生—内分泌]

 

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