血液灌流对大剂量阿米替林中毒患者血药浓度和预后的影响  

Effect of hemoperfusion on serum concentration and prognosis in patients with severe amitriptyline intoxication

作　　者：熊建琼[1] 张雷[1] 文亮[1] 谢先会[1] 

机构地区：[1]第三军医大学西南医院急救部ICU,重庆400038

出　　处：《重庆医学》2007年第10期951-951,954,共2页Chongqing medicine

摘　　要：目的研究血液灌流对大剂量阿米替林中毒患者血药浓度和预后的影响。方法大剂量阿米替林中毒患者16例。入院后除常规治疗外,同时行血液灌流治疗,并采用反相高效液相色谱法于灌流前后测定血浆阿米替林浓度。结果血液灌流后血浆阿米替林浓度与灌流前相比显著下降〔由(0.74±0.23)μg/ml降至(0.17±0.09)μg/ml〕,中毒症状明显改善。结论血液灌流能显著加快血中阿米替林的清除。Objective To study the effect of hemoperfusion on serum concentration and prognosis in the patients with severe amitriptyline intoxication. Methods Sixteen patients with severe amitriptyline intoxication were involved and hemoperfusion were performed. The serum concentration of amitriptyline were analyzed before and after hemoperfusion by use of reverse phase high per- formance liquid chromatography. Results The serum concentrations of amitriptyline were decreased from （0.74±0.23）μg/ml to （0. 17±0.09）μg/ml after hemoperfusion. The symptoms and signs of severe amitriptyline intoxication were improved obviously. Conclusion Hemoperfusion can eliminate serum amitripyline effectively.

关 键 词：血液灌流 阿米替林 中毒 血药浓度 

分 类 号：R595.4[医药卫生—内科学]