氟哌利多影响DA对吗啡成瘾大鼠痛觉的调制  

Role of droperidol in modulation of dopamine on central painful sense in morphinistic rats

作　　者：张颖[1] 苏洁[1] 徐满英[1] 

机构地区：[1]哈尔滨医科大学生理学教研室,黑龙江哈尔滨150086

出　　处：《中国药理学通报》2007年第5期594-597,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30240058)

摘　　要：目的观察多巴胺(dopamine,DA)及其DA受体拮抗剂氟哌利多对急性吗啡成瘾大鼠尾核中痛兴奋神经元(PEN)电活动的影响。方法腹腔注射递增剂量的盐酸吗啡使Wistar大鼠形成吗啡依赖。实验以电脉冲刺激大鼠坐骨神经作为伤害性痛刺激,用玻璃微电极记录尾核中PEN的放电变化。结果DA可使吗啡成瘾大鼠PEN的兴奋性降低。氟哌利多可以逆转DA对吗啡成瘾大鼠PEN的作用。结论DA对吗啡成瘾大鼠尾核中PEN有抑制作用。这种作用可以被DA受体拮抗剂阻断。Aim To observe the effect of dopamine （DA） and its antagonist on the electrical activities of pain excitation neurons （PEN） in the caudate nucleus （Cd） right of morphine dependent rats. Methods The sciatic nerve was stimulated by train of electrical impulses as noxious stimuli to morphine dependent rats.The electrical discharges of PEN in Cd were recorded with glass microelectrode to observe influences of intracerebroventricular （icy） injection of DA and droperidol on the electrical activities of PEN. Results DA could decrease excitabilities of PEN in Cd of morphine dependent rats. Conclusion Results suggest that the depression of DA on PEN response in Cd of morphine dependent rats might be blocked by droperidol.

关 键 词：多巴胺 尾核 痛兴奋神经元 

分 类 号：R332[医药卫生—人体生理学] R322.8[医药卫生—基础医学]