鼠神经生长因子在格林-巴利综合征治疗中促神经修复的作用  

Repair role of mouse nerve growth factor to peripheral nerve in Giullain-Barre syndrome

作　　者：刘洪波[1] 张炳谦[1] 方树友[1] 滕军放[1] 连亚军[1] 许予明[1] 张博爱[1] 

机构地区：[1]郑州大学第一附属医院神经科,河南郑州450052

出　　处：《中国新药与临床杂志》2007年第5期343-346,共4页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的:探讨鼠神经生长因子在格林-巴利综合征治疗中促周围神经修复的作用。方法:格林-巴利综合征脱髓鞘组98例,分为脱髓鞘治疗组(A)50例及脱髓鞘对照组(B)48例;格林-巴利综合征混合型组88例,分为混合型治疗组(C)45例,混合型对照组(D)43例。格林-巴利综合征单纯轴索病变组39例,分为轴索型治疗组(E)21例,轴索型对照组(F)18例。A,C,E组常规应用静脉注射丙种球蛋白0．4 g·kg^(-1)·d^(-1),连用5 d等治疗并加用鼠神经生长因子,B,D,F组仅常规应用静脉注射丙种球蛋白0．4g·kg^(-1)·d^(-1),连用5 d等治疗,疗程结束后做神经功能评价及肌电图评价。结果:脱髓鞘组中A组的明显好转、痊愈率及神经传导速度恢复明显高于B组,P＜0．05;混合型组中C组在明显好转、痊愈率及神经传导速度与波幅恢复较D组明显提高,P＜0．05;轴索型组中E,F组在临床明显好转及痊愈率无显著差异,P＞0．05,但波幅恢复E较F组明显提高,P＜0．05。结论:鼠神经生长因子对格林-巴利综合征周围神经髓鞘的再生和轴索的恢复有显著疗效。AIM： To study the repair role of mouse nerve growth factor （mNGF） in peripheral nerve for Guillain-Barre syndrome （GBS）. METHODS： GBS demyelination group 98 patients were divided into treatment group A 50 patients and controlled group B 48 patients; GBS mixed group 88 patients were divided into treatment group C 45 patients and controlled group D 43 patients; GBS axonal degeneration group 39 patients were divided into treatment group E ,21 patients and controlled group F 18 patients. A, C, E groups were treated with intravenous immunoglobulin 0.4 g·kg^-1·d^-1 for 5 d and mNGF for 2 mo individually; B, D, F groups were only treated with intravenous immunoglobulin 0.4 g·kg^-1·d^-1 for 5 d individually. Patients＇ nerve function and electromyogram （EMG） were evaluated at the beginning and end of the treatment. RESULTS： Recovery rate, full recovery rate and motor nerve conduction velocity （NCV） in A group Were more better than those in B group, P 〈 0.05. Recovery rate, full recovery rate, motor NCV and motor nerve wave range in C group were greatly better than those in D group, P 〈 0.05. Clinical recovery rates and full recovery rates showed no obvious difference between E and F group, P 〉 0.05, but motor nerve wave range in E group demonstrated obviously higher than that in F group, P 〈 0.05. CONCLUSION： mNGF possesses significant effect for the recovery of demyelination and axonal degeneration in GBS.

关 键 词：格林-巴利综合征 小鼠 神经生长因子 脱髓鞘疾病 轴索病变 

分 类 号：R977[医药卫生—药品] R745[医药卫生—药学]