血管紧张素Ⅱ1型受体基因A1166C多态性与新疆维吾尔族高血压相关性研究  

Association of AngiotensinⅡType 1 Receptor gene A1166C polymorphism with Essential Hypertension in Xinjiang Uygur population

作　　者：张丽萍[1] 汪师贞[2] 赵学信[1] 陈健刚[1] 蒲红伟[1] 王笑峰[3] 

机构地区：[1]新疆医科大学基础医学院生化教研室,新疆乌鲁木齐830054 [2]新疆医科大学第一附属医院心内科,新疆乌鲁木齐830054 [3]复旦大学生命科学院遗传研究所,上海200433

出　　处：《现代生物医学进展》2007年第5期718-720,共3页Progress in Modern Biomedicine

基　　金：国家自然科学基金(30500291)

摘　　要：目的:探讨新疆维吾尔族人群血管紧张素Ⅱ1型受体基因(AT1R)A1166C多态性与原发性高血压之间的关系,了解该基因多态在维吾尔族群体中的分布情况。方法:选择新疆维吾尔族原发性高血压病患者126例,正常血压者143例,应用多聚酶链反应、限制性片段长度多态性技术(PCR-RFLP)时入选样本进行基因分型。结果:AT1R基因A1166C多态符合Hardy-Weinberg平衡;AA、AC各基因型频率在维吾尔族病例组和对照组分别为73%、27%和74．8%、25．2%,差异无统计学意义(P＞0．05),C等位基因频率分别为13．5%和12．6%,差异亦无统计学意义(P＞0．05)。结论:AT1R基因A1166C多态可能不是新疆维吾尔族原发性高血压病的遗传易感指标。Objective： The rennin-angiotensin system （RAS） is implicated in the pathogenesis of hypertension Angiotension Ⅱ（Ang Ⅱ） is the biologically active peptide of the RAS and the effects of Ang II are mainly mediated by the angiotensin II type 1 receptor （AT1R）. To investigate the correlation between AT1R gene Al166C polymorphism with essential hypertension in Xinjiang Uygur population, and investigate the distribution of genotype and allele frequencies of AT1R gene. Methods：One hundred and twenty-six patients with essential hypertension and one hundred forty-three normal blood pressure controls were included in the study to assess the contribution of polymorphism of AT1R. Then the polymerase chain reaction- restriction fragment length polymorphism （PCR-RFLP） method was used for the detection AT1R genotype. Results：The genotypes of the variants were found to be in Hardy-Weinberg equilibrium in Uygur group , AA,AC frequencies of genotype were 73%,27%and 74.8%,25.2% in Eli and NT groups respectively. C allele frequencies were 13.5% and 12.6% respectively. Significant difference were not seen between EH and NT groups. （p 〉0.05）. Conclusions：Our results suggested that the AT1R gene A1166C polymorphism might be not associated with hypertension in Uygur population.

关 键 词：原发性高血压 血管紧张素Ⅱ1型受体基因 单核苷酸多态性 维吾尔族 

分 类 号：R544.1[医药卫生—心血管疾病]