孕期应激对子代影响及相关机制的探讨(英文)  

Alteration of Multiple Systems in Offspring After Prenatal Stress

作　　者：谢应桂[1] 莫晓叶[2] 王岐本[1] 李政[2] 

机构地区：[1]湘南学院基础医学部解剖教研室,湖南郴州423000 [2]中南大学湘雅医学院第二临床学院,03级七年制湖南长沙410013

出　　处：《现代生物医学进展》2007年第5期749-753,共5页Progress in Modern Biomedicine

基　　金：Scientific Research Foundation of Department of Education of Hunan Province(06C781)

摘　　要：孕期应激对子代的影响受到多种因素的影响。虽然目前机制尚不清楚,但是大量实验证明其可能与HPA轴活性的改变, NPY能系统,多巴胺系统和5-HT神经元有关。此外,研究影响孕期应激的各种因素之间的互相作用和联系有助于明确孕期应激对子代影响的具体机制。本文从神经内分泌、情绪、学习记忆等多方面综合分析了孕期应激对子代影响的特点,包括应激强度依赖性、时间差异性和个体差异性。This paper, from the aspects of neuroendocrine, emotion, learning etc, analyzed comprehensively the characteristics of the influence of prenatal stress （PS） on offspring, including intensity of PS, timing of exposure and individual differences. Despite the variety in methodology, most studies on it indicate that the prenatal stressful events lead to offspring＇s increased plasma glucocorticoid （GC） level, more depressed-related behaviors and impaired learning abilities. Although mechanism of prenatal stress is still unclear, most studies show that it is concerned with hypothalamio-pituitary-adneral （HPA） axis, dopaminergic （DA-ergic） system, neuropeptide Y （NPY） and serotoninergic （5-HT ergic） system. Moreover, further studies are proposed to pay more attention to the rdationship and interaction of various related substances.

关 键 词：孕期应激 子代 NPY 多巴胺 

分 类 号：R651.3[医药卫生—外科学]